2-Methoxy-5-nitrobenzotrifluoride

Product Overview

2-Methoxy-5-nitrobenzotrifluoride is a specialized fluorinated aromatic compound that serves as a critical building block in modern organic synthesis. Characterized by the presence of both a nitro group and a trifluoromethyl moiety on the benzene ring, this chemical intermediate offers unique reactivity profiles essential for constructing complex molecular architectures. Our facility produces this compound under stringent quality management systems to ensure consistency and reliability for downstream applications.

The incorporation of fluorine atoms into organic molecules is a cornerstone strategy in medicinal chemistry and agrochemical development. This specific derivative provides an excellent platform for further functionalization, allowing chemists to introduce diverse substituents through nucleophilic aromatic substitution or reduction reactions. The stability provided by the trifluoromethyl group enhances the metabolic profile of final products, making it a preferred choice for pharmaceutical research and development teams.

Technical Specifications

Physical and Chemical Properties

Understanding the physical properties of this intermediate is vital for process safety and efficiency. The compound exhibits a density of 1.392 g/cm3, indicating a relatively heavy molecular structure due to the fluorine content. It melts within the range of 79-81 degrees Celsius, which facilitates handling and purification processes such as recrystallization. The boiling point is recorded at 267.2 degrees Celsius at 760 mmHg, suggesting high thermal stability under standard pressure conditions.

Safety parameters are equally important for industrial handling. The flash point is established at 115.4 degrees Celsius, classifying it as a combustible material that requires standard precautions during storage and transport. The index of refraction is measured at 1.517, which can be used for identity confirmation and purity assessment via refractometry. These consistent physical constants ensure that every batch meets the rigorous demands of synthetic chemistry laboratories.

Industrial Applications

This fluorinated intermediate finds extensive utility across multiple high-value sectors. In the pharmaceutical industry, it acts as a key precursor for synthesizing active pharmaceutical ingredients (APIs) where fluorine substitution is required to improve bioavailability and binding affinity. The nitro group allows for versatile transformations into amines or other functional groups necessary for drug molecule assembly.

• Pharmaceutical Intermediates: Used in the synthesis of novel therapeutic agents.
• Agrochemical Production: Serves as a building block for advanced pesticides and herbicides.
• Dye Manufacturing: Employed in the creation of specialized organic pigments and dyes.

Quality Assurance and Storage

We maintain a robust quality assurance protocol that includes comprehensive testing via HPLC, GC-MS, and NMR spectroscopy. Each shipment is accompanied by a Certificate of Analysis (COA) to verify purity and identity. For storage, the product should be kept in closed containers at room temperature under normal storage and handling conditions. It remains stable when protected from moisture and direct sunlight. We offer flexible packing options, including 20kg cartons or custom configurations based on specific customer requirements, ensuring safe global delivery.