2-Piperazinyl-4-amino-6,7-dimethoxyquinazoline

Product Overview

2-Piperazinyl-4-amino-6,7-dimethoxyquinazoline is a high-value heterocyclic compound widely employed as a critical building block in the synthesis of advanced pharmaceutical intermediates. With a molecular formula of C14H19N5O2 and a molecular weight of 289.33 g/mol, this compound features a quinazoline core substituted with methoxy groups at positions 6 and 7, an amino group at position 4, and a piperazinyl moiety at position 2. Its well-defined structure makes it particularly suitable for the development of cardiovascular and neurological therapeutics.

Specifications

Industrial Applications

This compound serves primarily as a chemical intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs). Notably, it is utilized in the production pathway of Prazosin hydrochloride (CAS 19237-84-4), an alpha-1 adrenergic blocker used to treat hypertension and benign prostatic hyperplasia. Its structural complexity and functional group diversity enable efficient derivatization under controlled reaction conditions, supporting robust scale-up in GMP-compliant manufacturing environments.

• High chemical stability under standard storage conditions
• Excellent reactivity profile for nucleophilic substitution and coupling reactions
• Consistent batch-to-batch quality for reliable process performance
• Compliant with international regulatory standards for pharmaceutical intermediates

Handling and Storage

Store in a cool, dry, and tightly sealed container away from moisture, direct sunlight, and heat sources. Recommended storage temperature is below 25°C. Use appropriate personal protective equipment during handling to avoid inhalation or skin contact.

Packaging

Supplied in 25 kg fiberboard drums with inner polyethylene liners. Custom packaging options are available upon request to meet specific logistical or regulatory requirements.