2-(Trifluoromethoxy)nitrobenzene
- CAS No.1644-88-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-(Trifluoromethoxy)nitrobenzene (CAS 1644-88-8), a key fluorinated aromatic intermediate for advanced organic synthesis in pharmaceutical and agrochemical manufacturing.
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Product Overview
2-(Trifluoromethoxy)nitrobenzene (CAS 1644-88-8) is a fluorinated aromatic nitro compound widely employed as a versatile building block in complex organic synthesis. This specialty intermediate features a trifluoromethoxy group ortho to the nitro functionality on the benzene ring, imparting unique electronic and steric properties that are highly valuable in the development of active pharmaceutical ingredients (APIs), crop protection agents, and high-performance materials. Its molecular architecture enables selective transformations such as nucleophilic aromatic substitution, reduction to anilines, and cross-coupling reactions.
Specifications
| Molecular Formula | C₇H₄F₃NO₃ |
|---|---|
| Molecular Weight | 207.107 g/mol |
| Density | 1.5 ± 0.1 g/cm³ |
| Boiling Point | 208.4 ± 35.0 °C at 760 mmHg |
| Flash Point | 79.8 ± 25.9 °C |
| Vapour Pressure | 0.3 ± 0.4 mmHg at 25 °C |
| Refractive Index | 1.476 |
| Appearance | Light yellow transparent liquid |
| Assay | ≥98.0% |
Industrial Applications
As a critical intermediate in fine chemical manufacturing, 2-(Trifluoromethoxy)nitrobenzene serves as a precursor in multi-step syntheses requiring fluorine-containing motifs. Its primary utility lies in:
- Pharmaceutical R&D for constructing fluorinated scaffolds with enhanced metabolic stability and bioavailability.
- Agrochemical innovation, where the trifluoromethoxy group contributes to improved pest resistance and environmental persistence profiles.
- Materials science applications involving electron-deficient aromatic systems for specialty polymers or liquid crystals.
Stored in a cool, well-ventilated area away from heat and ignition sources, this compound is typically supplied in 200 kg drums or customized packaging to meet global regulatory and logistical requirements.
