2'-(Trifluoromethyl)acetophenone
- CAS No.17408-14-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2'-(Trifluoromethyl)acetophenone (CAS 17408-14-9), a key fluorinated intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
2'-(Trifluoromethyl)acetophenone is a valuable fluorinated aromatic ketone widely employed as a building block in complex organic synthesis. With its electron-withdrawing trifluoromethyl group positioned ortho to the acetyl functionality, this compound exhibits enhanced reactivity and selectivity in a range of transformations, making it particularly useful in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals.
Specifications
| Molecular Formula | C9H7F3O |
|---|---|
| Molecular Weight | 188.146 g/mol |
| CAS Number | 17408-14-9 |
| Appearance | Off-white crystalline powder |
| Assay | ≥98.0% |
| Melting Point | 15–17 °C |
| Boiling Point | 206.1 ± 40.0 °C at 760 mmHg |
| Density | 1.2 ± 0.1 g/cm³ |
| Flash Point | 84.4 ± 0.0 °C |
| Refractive Index | 1.447 |
Industrial Applications
This fluorinated ketone serves primarily as a high-value intermediate in multi-step synthetic routes. Its applications include:
- Construction of heterocyclic scaffolds in medicinal chemistry programs
- Synthesis of fluorinated analogs for structure-activity relationship (SAR) studies
- Preparation of ligands and catalysts in asymmetric synthesis
- Development of novel materials requiring thermal or metabolic stability imparted by the CF3 group
Due to the strong inductive effect of the trifluoromethyl moiety, 2'-(Trifluoromethyl)acetophenone often enhances the lipophilicity, bioavailability, and metabolic resistance of downstream molecules—critical attributes in modern drug design.
Handling and Storage
Store in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. Keep container tightly closed when not in use. Standard industrial hygiene practices should be followed during handling. Supplied in 25 kg drums or customized packaging per client specifications.
