Intermediates

2-(Trimethylsilyl)phenyl Trifluoromethanesulfonate

  • CAS No.88284-48-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-(Trimethylsilyl)phenyl Trifluoromethanesulfonate serves as a critical benzyne precursor for advanced organic synthesis and pharmaceutical R&D.

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Product Technical Details

Product Overview

2-(Trimethylsilyl)phenyl Trifluoromethanesulfonate, commonly known as TMS-phenyl triflate, is a highly specialized fluorinated reagent designed for complex organic synthesis. This compound acts as a premier precursor for the generation of benzyne intermediates under mild conditions, facilitating a wide range of cycloaddition and nucleophilic addition reactions. Our manufacturing process ensures exceptional purity levels, making it an ideal choice for demanding pharmaceutical research and new material development.

As a key building block in modern chemistry, this triflate derivative offers superior reactivity and stability. The combination of the trimethylsilyl group and the trifluoromethanesulfonate leaving group enables chemists to execute transformations that are otherwise difficult to achieve with traditional reagents. We supply this product with comprehensive technical support to assist in your synthesis route optimization.

Specifications

We adhere to strict quality control protocols to guarantee consistency across every batch. The following technical parameters reflect our standard commercial grade specifications, suitable for both laboratory scale and industrial applications.

ParameterValue
CAS Number88284-48-4
Molecular FormulaC10H13F3O3SSi
Molecular Weight298.35 g/mol
Density1.229 g/mL at 25ºC
Boiling Point70ºC at 2 mm Hg
Refractive Indexn20/D 1.456
AppearanceColorless liquid

Industrial Applications

This fluorinated reagent is extensively utilized across multiple high-tech sectors. Its primary application lies in the synthesis of complex aromatic compounds where benzyne intermediates are required. Key usage scenarios include:

  • Pharmaceutical Research and Development: Used in the synthesis of active pharmaceutical ingredients (APIs) requiring specific aromatic substitutions.
  • New Materials Manufacturing: Essential for creating advanced polymers and functional materials with unique electronic or structural properties.
  • Pesticide Development: Serves as a critical intermediate in the production of next-generation agrochemicals.
  • Organic Synthesis: Facilitates Diels-Alder reactions and other cycloadditions with high regioselectivity.

Quality Assurance and Supply

Our company is committed to establishing a complete fluorochemical products and technology platform. We provide convenient one-stop services ranging from raw material procurement to final quality control. Every shipment includes a Certificate of Analysis (COA) to verify industrial purity standards. As a global manufacturer, we ensure reliable bulk supply chains and competitive pricing for long-term partners. Our dedicated team supports customers with fluorination technology research and development, ensuring your projects meet stringent regulatory and performance benchmarks.