2,2,2-Trimethylthioacetamide
- CAS No.630-22-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2,2,2-Trimethylthioacetamide (CAS 630-22-8), a key pharmaceutical intermediate used in the synthesis of targeted kinase inhibitors.
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Product Overview
2,2,2-Trimethylthioacetamide (CAS 630-22-8) is a high-value thioamide compound widely employed as a critical building block in advanced pharmaceutical synthesis. With a molecular formula of C5H11NS and a molecular weight of 117.21 g/mol, this compound serves as an essential intermediate in the production of selective kinase inhibitors, including those used in oncology therapeutics. Its structural uniqueness enables efficient incorporation into complex active pharmaceutical ingredient (API) scaffolds under controlled manufacturing conditions.
Specifications
| Molecular Formula | C5H11NS |
|---|---|
| Molecular Weight | 117.21 g/mol |
| Appearance | White powder |
| Purity | ≥98.0% |
| Melting Point | 117–119°C |
| Boiling Point | 162.1°C |
| Density | 0.978 g/cm³ |
| Refractive Index | 1.513 |
| Flash Point | 51.9°C |
Industrial Applications
This thioamide derivative is primarily utilized as a synthetic intermediate in the multi-step preparation of targeted therapeutic agents. Its role in constructing sterically hindered amide motifs makes it particularly valuable in medicinal chemistry campaigns focused on improving metabolic stability and selectivity. The compound is not intended for direct human or veterinary use and is strictly supplied for research and industrial-scale API manufacturing under applicable regulatory frameworks.
- Key intermediate in kinase inhibitor synthesis pathways
- Enables introduction of tertiary alkyl-thioamide functionality
- Compatible with standard amide coupling and deprotection protocols
- Supplied with full analytical documentation including COA and spectral data
Storage recommendations include keeping the material in a cool, dry, and well-ventilated area away from ignition sources, consistent with its moderate flash point. Packaging is typically provided in 25 kg fiber drums, with custom options available upon request. Note that distribution may be restricted in regions where downstream products are protected by active intellectual property rights.
