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3-[(1S)-1-(Dimethylamino)ethyl]phenol
- CAS No.139306-10-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity chiral intermediate for the synthesis of Rivastigmine and its tartrate salt, widely used in neurological therapeutics manufacturing.
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Product Overview
3-[(1S)-1-(Dimethylamino)ethyl]phenol is a high-value chiral building block primarily employed as a key pharmaceutical intermediate in the synthesis of Rivastigmine (CAS 123441-03-2) and Rivastigmine tartrate (CAS 129101-54-8). This compound features a well-defined stereochemistry at the benzylic carbon, which is critical for ensuring the pharmacological efficacy and regulatory compliance of the final active pharmaceutical ingredient (API). As a structurally defined impurity reference standard—often designated as Rivastigmine Related Compound C—it also plays an essential role in analytical method development and quality control during API production.
Specifications
| Molecular Formula | C₁₀H₁₅NO |
|---|---|
| Molecular Weight | 165.23 g/mol |
| Density | 1.041 g/cm³ |
| Boiling Point | 237.3°C at 760 mmHg |
| Melting Point | 87–88°C |
| Refractive Index | 1.539 |
| Appearance | Off-white to light yellow powder |
| Assay (Purity) | ≥99% |
| Isomer Assay | ≤0.5% |
| Water (K.F.) | ≤0.5% |
| Max Single Impurity | ≤0.5% |
| Related Substances | ≤1.0% |
| Residue on Ignition | ≤0.2% |
Industrial Applications
This enantiomerically enriched phenolic amine serves exclusively as a synthetic intermediate in advanced organic synthesis pathways targeting neurological therapeutics. Its primary industrial utility lies in:
- Enabling stereoselective construction of the carbamate core in acetylcholinesterase inhibitors.
- Supporting GMP-compliant manufacturing of APIs for Alzheimer’s and Parkinson’s disease treatments.
- Functioning as a reference material for impurity profiling and stability-indicating assays.
Due to its sensitivity to moisture and thermal degradation, the compound must be handled under controlled conditions. Recommended storage includes a cool, dry, and tightly sealed container, protected from direct light and heat sources. Standard packaging is provided in 25 kg fiberboard drums, with custom configurations available upon request to meet global regulatory and logistical requirements.
