Intermediates

3-[3-(Trifluoromethyl)phenyl]propanal

  • CAS No.21172-41-8
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 3-[3-(Trifluoromethyl)phenyl]propanal is a key pharmaceutical intermediate used primarily in the synthesis of Cinacalcet hydrochloride. We offer bulk quantities with strict quality control and comprehensive documentation.

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Product Technical Details

Product Overview

3-[3-(Trifluoromethyl)phenyl]propanal is a specialized organic compound characterized by the presence of a trifluoromethyl group on the phenyl ring. This structural feature significantly enhances the lipophilicity and metabolic stability of downstream pharmaceutical products. As a critical building block in medicinal chemistry, this aldehyde derivative serves as a vital precursor in the manufacturing of advanced therapeutic agents. Our facility produces this chemical under stringent quality management systems to ensure consistency and reliability for large-scale pharmaceutical synthesis.

Technical Specifications

We maintain rigorous standards for all batches to meet the demanding requirements of API manufacturing. The following table outlines the key physical and chemical properties verified during our quality control process.

ParameterSpecification
CAS Number21172-41-8
Molecular FormulaC10H9F3O
Molecular Weight202.17 g/mol
AppearanceColorless transparent liquid
Purity≥99.0%
Density1.192 g/cm3
Boiling Point207.4°C at 760 mmHg
Flash Point93.1°C
Refractive Index1.450

Industrial Applications

The primary application of 3-[3-(Trifluoromethyl)phenyl]propanal is in the synthesis of Cinacalcet hydrochloride, a calcimimetic agent used to treat secondary hyperparathyroidism and parathyroid carcinoma. The incorporation of the trifluoromethyl moiety is essential for the biological activity and pharmacokinetic profile of the final drug substance. Beyond this specific application, this intermediate is valuable in various organic synthesis routes where fluorinated aromatic aldehydes are required. Researchers and process chemists utilize this compound for developing new analogues and optimizing reaction pathways in drug discovery programs.

Quality Assurance and Storage

Our commitment to quality extends beyond mere purity specifications. Each production batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing all test results. We employ advanced analytical techniques such as HPLC and GC-MS to verify identity and assay. To maintain stability, the product should be stored in a tightly closed container at temperatures below -20°C in a freezer. It is crucial to keep the material in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizing agents. We offer flexible packaging options, including 25kg cardboard drums, or custom solutions based on specific client logistics requirements. Our global supply chain ensures timely delivery while maintaining the integrity of the chemical throughout transit.