Intermediates

3-(3-(Trifluoromethyl)phenyl)propanoic acid

  • CAS No.585-50-2
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 3-(3-(Trifluoromethyl)phenyl)propanoic acid (CAS 585-50-2) designed for pharmaceutical synthesis, specifically serving as a key intermediate for Cinacalcet production with ≥99.0% assay.

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Product Technical Details

Product Overview

3-(3-(Trifluoromethyl)phenyl)propanoic acid is a specialized fluorinated organic compound that plays a critical role in modern medicinal chemistry and pharmaceutical manufacturing. Characterized by the presence of a trifluoromethyl group on the phenyl ring, this chemical building block offers enhanced metabolic stability and lipophilicity when incorporated into complex drug molecules. Our facility produces this intermediate under strict quality control protocols to ensure consistency and reliability for downstream synthesis processes.

As a leading global manufacturer, we understand the demanding requirements of the pharmaceutical industry. This compound is particularly valued for its utility in the synthesis of calcimimetic agents, most notably serving as a essential precursor in the production of Cinacalcet. The introduction of fluorine atoms into organic structures is a strategic move in drug design to improve bioavailability and binding affinity, making this propanoic acid derivative a high-demand item in advanced organic synthesis pipelines.

Technical Specifications

We maintain rigorous standards for all our chemical intermediates. The following table outlines the key physicochemical properties and quality parameters for this product batch. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) to verify compliance with specified limits.

ParameterSpecification
CAS Number585-50-2
Molecular FormulaC10H9F3O2
Molecular Weight218.173 g/mol
AppearanceYellow liquid
Assay (Purity)≥99.0%
Water Content≤0.50%
Boiling Point268.7±35.0 °C at 760 mmHg
Density1.3±0.1 g/cm3
Refractive Index1.475
Flash Point116.3±25.9 °C

Industrial Applications

The primary application of 3-(3-(Trifluoromethyl)phenyl)propanoic acid lies in the pharmaceutical sector, specifically within the manufacturing chain for therapeutic agents targeting parathyroid disorders. Its structural configuration allows for efficient coupling reactions and functional group transformations required to build the active pharmaceutical ingredient (API). Beyond Cinacalcet, this fluorinated acid serves as a versatile building block for various research and development projects involving aromatic substitution and chain elongation.

Chemists utilize this intermediate to explore structure-activity relationships (SAR) where the trifluoromethyl moiety is required to modulate the electronic properties of the final molecule. The high purity level ensures that side reactions are minimized during synthesis, leading to higher overall yields and reduced purification costs for our clients. We support both large-scale commercial production and smaller batch requirements for clinical trial material synthesis.

Quality Assurance and Storage

Quality assurance is the cornerstone of our operation. Every batch undergoes multiple stages of testing using advanced analytical techniques such as HPLC and NMR to confirm identity and purity. We adhere to international safety standards to ensure that the product reaches our partners in optimal condition. The material is packaged in secure 25kg drums, though custom packaging solutions are available to meet specific logistical needs.

For optimal stability, this chemical should be stored in a cool, dry, and well-ventilated area. Containers must remain tightly closed to prevent moisture absorption and contamination. Proper handling procedures should be followed according to safety data sheets (SDS) to ensure workplace safety. As a trusted supplier, we commit to providing consistent quality, competitive bulk pricing, and reliable global shipping for all our pharmaceutical intermediates.