3,4,5-Trifluorobenzonitrile
- CAS No.134227-45-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity 3,4,5-Trifluorobenzonitrile (CAS 134227-45-5) for advanced organic synthesis. Reliable supply with ≥99.0% assay and global shipping options.
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Product Overview
3,4,5-Trifluorobenzonitrile represents a critical fluorinated building block within the realm of advanced organic chemistry. Characterized by its unique substitution pattern, this compound serves as an essential precursor for the development of complex pharmaceutical agents and agrochemical formulations. The presence of three fluorine atoms on the benzene ring significantly enhances the metabolic stability and lipophilicity of downstream molecules, making it a preferred choice for medicinal chemists aiming to optimize drug candidates.
Our manufacturing process ensures consistent quality and high purity levels, adhering to strict international standards. We understand the demanding requirements of modern synthesis routes, which is why our production facilities are equipped to handle fluorinated compounds with precision and safety. Whether utilized in cross-coupling reactions or nucleophilic substitutions, this nitrile derivative provides reliable reactivity profiles for diverse chemical transformations.
Key Specifications
Quality control is paramount in the supply of fine chemical intermediates. Each batch undergoes rigorous testing to verify physical and chemical properties. The following table outlines the standard specifications for our commercial grade 3,4,5-Trifluorobenzonitrile:
| Parameter | Value |
|---|---|
| CAS Number | 134227-45-5 |
| Molecular Formula | C7H2F3N |
| Molecular Weight | 157.093 g/mol |
| Appearance | White to light yellow crystalline powder |
| Assay (Purity) | ≥99.0% |
| Moisture Content | ≤0.5% |
| Boiling Point | 190.5±0.0 °C at 760 mmHg |
| Melting Point | 45-47 °C |
| Density | 1.4±0.1 g/cm3 |
Industrial Applications
This fluorinated nitrile is predominantly employed as an intermediate in the synthesis of high-value organic compounds. Its primary applications include pharmaceutical intermediate usage in the construction of kinase inhibitors and other therapeutic molecules where fluorine substitution is required to improve bioavailability. It also serves as a building block for novel pesticides and herbicides that require enhanced environmental stability in agrochemical synthesis.
In material science, it is utilized in the development of specialized polymers and liquid crystals where specific electronic properties are needed. The versatility of the nitrile group allows for further functionalization into amines, acids, or tetrazoles, providing chemists with a flexible platform for molecular design and innovation.
Quality Assurance and Packaging
We are committed to delivering products that meet exacting standards. Every shipment is accompanied by a Certificate of Analysis (COA) to verify compliance with specified parameters. Our packaging solutions are designed to maintain product integrity during transit. Standard packing is 25 kg per drum, with custom packaging available upon customer request to suit specific logistical needs.
Safety handling protocols should be strictly followed during use. Personnel must wear appropriate protective equipment including gloves and safety goggles. Use only in a well-ventilated fume hood to avoid inhalation of dust or vapors. In case of contact with skin, wash immediately with plenty of water. Proper disposal methods must be adhered to according to local environmental regulations. As a global manufacturer, we ensure reliable supply chains and competitive bulk pricing for long-term partners.
