3,4,5-Trifluorophenylboronic acid
- CAS No.143418-49-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3,4,5-Trifluorophenylboronic acid (CAS 143418-49-9) designed for advanced organic synthesis and Suzuki coupling reactions.
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Product Overview
3,4,5-Trifluorophenylboronic acid is a specialized arylboronic acid derivative characterized by the presence of three fluorine atoms on the phenyl ring. This unique structural configuration enhances its electronic properties, making it an invaluable building block in modern medicinal chemistry and agrochemical development. As a key intermediate, it facilitates the construction of complex molecular architectures through cross-coupling reactions, particularly the Suzuki-Miyaura coupling. Our manufacturing process ensures consistent quality and high purity levels suitable for demanding research and industrial applications.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 143418-49-9 |
| Molecular Formula | C6H4BF3O2 |
| Molecular Weight | 175.90 g/mol |
| Appearance | White to off-white crystalline solid |
| Assay (Purity) | ≥98.0% |
| Moisture Content | ≤0.2% |
| Density | 1.44 g/cm3 |
| Boiling Point | 263.6°C |
| Flash Point | 113.2°C |
| Refractive Index | 1.423-1.425 |
Industrial Applications
This fluorinated boronic acid serves as a critical reagent in the synthesis of pharmaceutical active ingredients (APIs) and functional materials. The electron-withdrawing nature of the fluorine substituents modulates the reactivity of the boron center, allowing for precise control during catalytic cycles. Common applications include:
- Synthesis of kinase inhibitors and other therapeutic agents.
- Development of novel agrochemical compounds with enhanced metabolic stability.
- Construction of liquid crystals and organic electronic materials.
- Utilization in Suzuki-Miyaura cross-coupling reactions for C-C bond formation.
Quality Assurance and Storage
We adhere to strict quality control protocols to ensure every batch meets international standards. Each production lot undergoes rigorous testing using HPLC, NMR, and GC analysis to verify identity and purity. A Certificate of Analysis (COA) is provided with every shipment. For optimal stability, the product should be stored in a cool, ventilated area away from moisture and strong oxidizing agents. The standard packaging is 25 kg per drum, though custom packaging solutions are available to meet specific logistical requirements. Our global supply chain ensures timely delivery to support your production schedules.
