3-(4-Chlorobutyl)-1H-indole-5-carbonitrile
- CAS No.143612-79-7
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity pharmaceutical intermediate essential for the synthesis of Vilazodone and Veratrazodone. Available in bulk quantities with full documentation.
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Product Overview
3-(4-Chlorobutyl)-1H-indole-5-carbonitrile is a highly specialized pharmaceutical intermediate designed for use in complex organic synthesis pathways. This compound features a robust indole scaffold substituted with a chlorobutyl chain and a nitrile group, making it an essential building block for the development of advanced neurological therapeutics. Our facility produces this chemical under strict quality control protocols to ensure consistency and reliability for downstream API manufacturing.
As a key precursor, this material plays a critical role in the construction of molecules targeting serotonin receptors. The structural integrity of the indole ring combined with the reactive chlorobutyl side chain allows for versatile coupling reactions, facilitating efficient synthesis routes for high-value pharmaceutical agents. We prioritize molecular stability and purity to support rigorous research and production scales.
Technical Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | 3-(4-Chlorobutyl)-1H-indole-5-carbonitrile |
| CAS Number | 143612-79-7 |
| Molecular Formula | C13H13ClN2 |
| Molecular Weight | 232.73 g/mol |
| Appearance | White powder |
| Purity | ≥99.0% |
| Density | 1.314 g/cm3 |
| Boiling Point | 489.85°C at 760 mmHg |
| Flash Point | 250.05°C |
Industrial Applications
This intermediate is primarily utilized in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs) focused on mental health treatments. Specifically, it serves as a crucial synthon in the manufacturing processes of Vilazodone and Veratrazodone hydrochloride. These final products are known for their efficacy in treating depression and anxiety disorders, highlighting the importance of high-quality starting materials.
- Essential building block for serotonin modulator synthesis.
- Used in the production of antidepressant and anxiolytic APIs.
- Supports scalable manufacturing for clinical and commercial batches.
- Compatible with standard alkylation and substitution reactions.
Quality Assurance and Storage
We understand that the quality of intermediates directly impacts the safety and efficacy of the final drug product. Therefore, every batch of 3-(4-Chlorobutyl)-1H-indole-5-carbonitrile undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to verify identity and purity. A Certificate of Analysis (COA) is provided with every shipment to ensure full traceability and compliance with industry standards.
Proper storage is vital to maintain the chemical stability of this compound. It should be stored in a cool, dry, and well-closed container, protected from moisture and strong light or heat sources. Our packaging options include 25kg cardboard drums or custom configurations based on specific customer requirements, ensuring safe global transportation and handling.
