3,4-Difluorobenzyl Bromide
- CAS No.85118-01-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3,4-Difluorobenzyl Bromide (CAS 85118-01-0), a key fluorinated intermediate for advanced organic synthesis in pharmaceutical and agrochemical manufacturing.
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Product Overview
3,4-Difluorobenzyl Bromide is a high-value fluorinated aromatic halide widely employed as a versatile building block in modern organic synthesis. With its dual ortho-fluorine substitution and reactive benzylic bromide functionality, this compound serves as a critical intermediate in the construction of complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. Its electron-deficient aromatic ring enhances reactivity in cross-coupling reactions, making it indispensable in medicinal chemistry workflows.
Specifications
| Molecular Formula | C₇H₅BrF₂ |
|---|---|
| Molecular Weight | 207.02 g/mol |
| CAS Number | 85118-01-0 |
| Appearance | Off-white to white powder |
| Purity | ≥99.0% |
| Density | 1.618 g/cm³ |
| Boiling Point | 59–61°C |
| Flash Point | 175°F (79.4°C) |
| Refractive Index | 1.526 |
Industrial Applications
As a specialized fluoroaromatic intermediate, 3,4-Difluorobenzyl Bromide is primarily utilized in the following industrial contexts:
- Serving as a precursor in the synthesis of fluorinated pharmaceutical candidates targeting central nervous system disorders and metabolic diseases.
- Enabling Suzuki, Negishi, and other palladium-catalyzed cross-coupling reactions to introduce the 3,4-difluorobenzyl moiety into lead compounds.
- Acting as an alkylating agent in the preparation of heterocyclic scaffolds for crop protection agents.
- Supporting structure-activity relationship (SAR) studies through rapid derivatization in drug discovery pipelines.
Our product is manufactured under stringent quality control protocols to ensure batch-to-batch consistency, with comprehensive Certificates of Analysis (COA) available upon request. Standard packaging is 25 kg per drum, with custom options accommodated for large-scale industrial procurement. Store in a cool, dry, and well-ventilated area away from light and moisture to maintain stability.
