3,4-Difluoronitrobenzene
- CAS No.369-34-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3,4-Difluoronitrobenzene (CAS 369-34-6) is a key fluorinated aromatic intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
3,4-Difluoronitrobenzene (CAS 369-34-6) is a high-value fluorinated aromatic compound widely employed as a versatile building block in the synthesis of complex organic molecules. With its dual fluorine substituents and electron-withdrawing nitro group, this intermediate offers exceptional reactivity and selectivity in nucleophilic aromatic substitution (SNAr), cross-coupling reactions, and reduction pathways. It serves as a critical precursor in the development of active pharmaceutical ingredients (APIs), specialty agrochemicals, and advanced materials requiring precise electronic and steric tuning.
Specifications
| Molecular Formula | C6H3F2NO2 |
|---|---|
| Molecular Weight | 159.09 g/mol |
| Density | 1.437 g/cm³ |
| Boiling Point | 76–80 °C |
| Flash Point | 177 °F (80.6 °C) |
| Refractive Index | 1.509 |
| Appearance | Khaki tan liquid (clear, colorless to light yellow) |
| Assay (GC) | ≥99.0% (Typical: 99.60%) |
| Moisture | ≤0.2% (Typical: 0.02%) |
Industrial Applications
As a strategic intermediate in fine chemical manufacturing, 3,4-Difluoronitrobenzene enables the efficient construction of fluorinated scaffolds essential for modern drug discovery and crop protection chemistry. Its applications include:
- Serving as a core synthon for fluorinated anilines via controlled nitro-group reduction.
- Facilitating Pd-catalyzed cross-coupling reactions to generate biaryl architectures.
- Acting as a starting material for heterocyclic systems such as benzimidazoles and quinazolines.
- Supporting the synthesis of liquid crystals and electronic materials requiring defined dipole moments.
Manufactured under stringent quality control protocols, our product conforms to factory standards and is ideal for scale-up in GMP-compliant environments. Packaging is available in 200 kg drums or customized configurations upon request. Store in a cool, well-ventilated area away from heat and ignition sources.
