Intermediates

3,4-Difluorophenyl Isothiocyanate

  • CAS No.113028-75-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 3,4-Difluorophenyl Isothiocyanate for advanced organic synthesis. Reliable supply with COA.

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Product Technical Details

Product Overview

3,4-Difluorophenyl Isothiocyanate is a highly specialized fluorinated building block designed for complex organic synthesis applications. As a key intermediate in the pharmaceutical and agrochemical industries, this compound offers exceptional reactivity due to the presence of the isothiocyanate functional group combined with the electron-withdrawing properties of the difluoro substitution pattern. Our manufacturing process ensures consistent quality and high purity levels, making it an ideal choice for research and development teams focused on novel molecule discovery.

The introduction of fluorine atoms into organic molecules often enhances metabolic stability and bioavailability, which is critical in modern drug design. This product serves as a versatile precursor for the synthesis of ureas, thioureas, and heterocyclic compounds. We adhere to strict quality control protocols to guarantee that every batch meets the rigorous standards required for industrial-scale production and laboratory research.

Technical Specifications

ParameterValue
Chemical Name3,4-Difluorophenyl Isothiocyanate
CAS Number113028-75-4
Molecular FormulaC7H3F2NS
Molecular Weight171.17 g/mol
AppearanceYellow liquid
Assay≥99.0%
Density1.26 g/cm3
Boiling Point236.7ºC at 760 mmHg
Flash Point97ºC

Industrial Applications

This fluorinated isothiocyanate is extensively utilized in the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals. The isothiocyanate group is highly reactive towards nucleophiles such as amines and alcohols, facilitating the formation of stable bonds in complex molecular architectures. Common applications include the development of kinase inhibitors, receptor modulators, and specialized agrochemical agents.

  • Pharmaceutical Intermediate: Used in the construction of heterocyclic cores for drug candidates.
  • Agrochemical Synthesis: Acts as a building block for novel pesticides and herbicides.
  • Material Science: Employed in the modification of polymers and surface coatings.
  • Research Reagent: Essential for medicinal chemistry programs exploring structure-activity relationships.

Quality Assurance and Storage

We prioritize product integrity through comprehensive testing procedures. Each shipment is accompanied by a Certificate of Analysis (COA) detailing purity, identity, and physical properties. Our facility maintains optimal storage conditions to prevent degradation. Users should store this material in a cool, ventilated area away from direct sunlight and moisture. Proper handling procedures, including the use of personal protective equipment, are recommended to ensure safety during laboratory or industrial operations. For bulk orders, custom packaging solutions are available to meet specific logistical requirements.