Intermediates

3,4-Difluorophenylboronic Acid

  • CAS No.168267-41-2
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 3,4-Difluorophenylboronic Acid (CAS 168267-41-2) designed for advanced organic synthesis and pharmaceutical intermediate manufacturing.

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Product Technical Details

Product Overview

3,4-Difluorophenylboronic Acid is a highly specialized organoboron compound that serves as a critical building block in modern organic synthesis. Characterized by the presence of two fluorine atoms at the meta and para positions of the phenyl ring, this chemical exhibits unique electronic properties that enhance its reactivity in cross-coupling reactions. Our manufacturing process ensures exceptional purity levels, making it an ideal choice for researchers and industrial chemists focused on developing complex pharmaceutical agents and advanced materials.

The introduction of fluorine substituents into organic molecules is a strategic approach in medicinal chemistry to improve metabolic stability, lipophilicity, and bioavailability. As a key intermediate, this boronic acid derivative facilitates the construction of biaryl structures through palladium-catalyzed coupling methodologies. We adhere to strict quality control protocols to guarantee consistency across every batch, supporting seamless scale-up from laboratory research to commercial production.

Technical Specifications

Parameter Specification
CAS Number 168267-41-2
Molecular Formula C6H5BF2O2
Molecular Weight 157.91 g/mol
Appearance Off-white solid
Assay (Purity) ≥99.0%
Moisture Content ≤0.2%
Melting Point 305-310°C
Density 1.354 g/cm3

Industrial Applications

This compound is primarily utilized as a versatile reagent in Suzuki-Miyaura cross-coupling reactions, enabling the efficient formation of carbon-carbon bonds. Its applications span across multiple high-value sectors, including the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and organic electronic materials. The specific fluorination pattern offers distinct advantages in tuning the physicochemical properties of final products, making it indispensable for drug discovery programs targeting neurological and oncological therapies.

Beyond pharmaceuticals, 3,4-Difluorophenylboronic Acid is employed in the development of liquid crystals and polymers where precise structural control is required. Our global supply chain ensures timely delivery for both pilot-scale experiments and large-scale manufacturing needs. We provide comprehensive technical support, including certificates of analysis (COA) and detailed safety data sheets to facilitate regulatory compliance and safe handling procedures.

Quality Assurance and Packaging

Quality is the cornerstone of our production philosophy. Each batch undergoes rigorous testing using advanced analytical techniques such as HPLC and NMR to verify identity and purity. We understand the importance of material integrity in sensitive synthetic pathways. Therefore, our packaging solutions are designed to protect the product from moisture and environmental contaminants during transit. Standard packaging includes 25 kg drums, with customized options available to meet specific logistical requirements. Store in a cool, ventilated place to maintain optimal stability over extended periods.