3,6-Dichloropyridazine
- CAS No.141-30-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3,6-Dichloropyridazine (CAS 141-30-0), a key building block for pharmaceutical intermediates such as Sulfachloropyridazine.
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Product Overview
3,6-Dichloropyridazine (CAS 141-30-0) is a high-value heterocyclic compound widely employed as a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its rigid diazine core substituted with two chlorine atoms at positions 3 and 6 offers excellent reactivity for nucleophilic aromatic substitution, enabling efficient derivatization in multi-step syntheses. This compound serves as a foundational scaffold in the production of sulfonamide-based therapeutics, including Sulfachloropyridazine (CAS 80-32-0).
Specifications
| Molecular Formula | C4H2Cl2N2 |
|---|---|
| Molecular Weight | 148.98 g/mol |
| Melting Point | 65–69 °C (lit.) |
| Boiling Point | 277.0 ± 20.0 °C at 760 mmHg |
| Density | 1.5 ± 0.1 g/cm³ |
| LogP | 0.90 |
| Appearance | White or off-white crystalline solid |
| Assay | ≥99.0% |
| Loss on Drying (IR-lamp) | ≤0.1% |
| Water Content (K.F.) | ≤0.1% |
Industrial Applications
As a versatile synthetic intermediate, 3,6-Dichloropyridazine is primarily utilized in the pharmaceutical industry for constructing complex molecular architectures. Its applications include:
- Serving as a precursor in the manufacture of sulfonamide antibiotics like Sulfachloropyridazine.
- Enabling the development of novel neurological and anti-infective therapeutics through regioselective functionalization.
- Supporting advanced organic synthesis campaigns requiring halogenated diazine motifs.
Due to its sensitivity to moisture and thermal degradation, it must be stored in a cool, dry, and well-ventilated environment with the container tightly sealed. Standard packaging is 25 kg per drum, with custom configurations available upon request.
