3-Amino-2-fluoropyridine
- CAS No.1597-33-7
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Amino-2-fluoropyridine (CAS 1597-33-7), a key fluorinated heterocyclic intermediate for pharmaceutical R&D and API synthesis.
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Product Overview
3-Amino-2-fluoropyridine (CAS 1597-33-7) is a high-value fluorinated heterocyclic compound widely employed as a critical building block in the synthesis of advanced pharmaceutical intermediates. With its unique combination of an amino group and a fluorine atom on the pyridine ring, it offers versatile reactivity for cross-coupling, nucleophilic substitution, and cyclization reactions, making it indispensable in modern medicinal chemistry workflows.
Specifications
| Molecular Formula | C5H5FN2 |
|---|---|
| Molecular Weight | 112.11 g/mol |
| Appearance | Yellow liquid |
| Purity | ≥99.0% |
| Density | 1.3 ± 0.1 g/cm³ |
| Boiling Point | 243.2 ± 20.0 °C at 760 mmHg |
| Flash Point | 100.9 ± 21.8 °C |
| Refractive Index | 1.554 |
| Packaging | 25 kg/drum |
| Storage | Store in a tightly closed container in a cool, dry place |
Industrial Applications
As a specialized fluoro-heterocyclic intermediate, 3-Amino-2-fluoropyridine serves as a foundational scaffold in the development of complex pharmaceutical APIs, particularly in neurological therapeutics and targeted kinase inhibitors. Its strategic placement of fluorine enhances metabolic stability and bioavailability in drug candidates.
- Ideal for Suzuki, Buchwald-Hartwig, and other Pd-catalyzed transformations
- Enables rapid diversification of molecular libraries in early-stage drug discovery
- Consistent batch-to-batch quality ensures reliable performance in GMP-compliant synthesis
- Sourced from ISO-certified manufacturing facilities with full traceability
