3-Amino-4-(trifluoromethoxy)bromobenzene
- CAS No.886762-08-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-amino-4-(trifluoromethoxy)bromobenzene (CAS 886762-08-9), a versatile fluorinated aromatic intermediate for advanced organic synthesis.
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Product Overview
3-Amino-4-(trifluoromethoxy)bromobenzene is a high-value fluorinated aromatic building block widely employed in the pharmaceutical and agrochemical industries. With its unique combination of bromo, amino, and trifluoromethoxy functional groups, this compound serves as a strategic intermediate in cross-coupling reactions, heterocycle formation, and the synthesis of complex bioactive molecules. Its molecular architecture enables precise regioselective transformations, making it indispensable in modern medicinal chemistry workflows.
Specifications
| Molecular Formula | C7H5BrF3NO |
|---|---|
| Molecular Weight | 256.020 g/mol |
| Density | 1.7 ± 0.1 g/cm³ |
| Boiling Point | 230.2 ± 35.0 °C at 760 mmHg |
| Flash Point | 93.0 ± 25.9 °C |
| Vapour Pressure | 0.1 ± 0.5 mmHg at 25°C |
| Index of Refraction | 1.523 |
| Assay | ≥98.0% |
| Appearance | Light yellow transparent liquid |
Industrial Applications
This fluorinated aniline derivative is primarily utilized as a key intermediate in multi-step organic syntheses. Its bromine atom facilitates palladium-catalyzed couplings (e.g., Suzuki, Buchwald-Hartwig), while the electron-withdrawing trifluoromethoxy group modulates reactivity and enhances metabolic stability in target molecules. Common applications include:
- Synthesis of novel kinase inhibitors and GPCR-targeted therapeutics
- Construction of fluorinated scaffolds for crop protection agents
- Preparation of specialty polymers with enhanced thermal and chemical resistance
Stored in a cool, well-ventilated area away from oxidizing agents, this product is typically supplied in 200 kg drums or customized packaging to meet stringent industrial requirements.
