3-Bromo-1,1,1-trifluoroacetone
- CAS No.431-35-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Bromo-1,1,1-trifluoroacetone (CAS 431-35-6), a versatile fluorinated intermediate for pharmaceutical R&D and advanced organic synthesis.
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Product Overview
3-Bromo-1,1,1-trifluoroacetone (CAS 431-35-6) is a highly reactive fluorinated α-halo ketone widely employed as a key building block in medicinal chemistry and agrochemical innovation. Its unique combination of an electron-withdrawing trifluoromethyl group and a bromine leaving group enables diverse nucleophilic substitution and condensation reactions, making it invaluable in the construction of complex fluorinated scaffolds.
Specifications
| Molecular Formula | C₃H₂BrF₃O |
|---|---|
| Molecular Weight | 190.95 g/mol |
| Appearance | Light yellow liquid |
| Density | 1.839 g/mL at 25 °C |
| Boiling Point | 87 °C at 743 mmHg |
| Melting Point | < -80 °C |
| Flash Point | 41 °F (5 °C) |
| Refractive Index | n²⁰/D 1.376 |
| Storage Conditions | Store in a flammables area under inert atmosphere, protected from moisture and light |
Industrial Applications
This fluorinated intermediate serves critical roles across multiple high-tech sectors:
- Pharmaceutical research: Enables synthesis of fluorinated analogs to enhance metabolic stability, bioavailability, and target affinity in drug candidates.
- Agrochemical development: Used in constructing novel pesticide molecules with improved environmental persistence and efficacy profiles.
- Advanced materials: Contributes to the design of specialty polymers and electronic materials requiring precise fluorine incorporation.
- Organic synthesis: Functions as a versatile electrophile in C–C and C–heteroatom bond-forming reactions, including aldol condensations and heterocycle formations.
As part of our comprehensive fluorochemical platform, we ensure stringent quality control from raw material sourcing through final product validation, delivering consistent batch-to-batch reliability for demanding industrial applications.
