Intermediates

3-Bromo-2-chloro-5-fluoropyridine

  • CAS No.884494-36-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

Premium grade 3-Bromo-2-chloro-5-fluoropyridine (CAS 884494-36-4) designed for high-efficiency organic synthesis. Reliable supply with strict quality control for pharmaceutical and agrochemical applications.

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Product Technical Details

Product Overview

3-Bromo-2-chloro-5-fluoropyridine is a highly versatile halogenated pyridine derivative that serves as a critical building block in modern organic synthesis. Characterized by its unique substitution pattern featuring bromine, chlorine, and fluorine atoms on the pyridine ring, this compound offers exceptional reactivity for various cross-coupling and nucleophilic substitution reactions. Our facility produces this intermediate under stringent quality management systems to ensure consistency and reliability for downstream chemical manufacturing processes.

As a key component in the development of advanced pharmaceuticals and agrochemicals, this fluorinated pyridine derivative enables chemists to introduce specific functional groups with high precision. The presence of multiple halogen atoms allows for selective functionalization, making it an invaluable asset in medicinal chemistry and fine chemical production. We are committed to supplying global partners with materials that meet rigorous international standards for purity and performance.

Key Specifications

To guarantee optimal performance in your synthesis workflows, we maintain tight control over physical and chemical parameters. The following table outlines the standard specifications for our commercial grade material:

ParameterSpecification
CAS Number884494-36-4
Molecular FormulaC5H2BrClFN
Molecular Weight210.432 g/mol
AppearanceWhite to off-white solid
Assay (Purity)≥98.0%
Moisture Content≤0.5%
Density1.8±0.1 g/cm3
Boiling Point202.6±35.0 °C at 760 mmHg
Flash Point76.3±25.9 °C

Industrial Applications

This compound is primarily utilized as an organic synthesis intermediate in the creation of complex molecular structures. Its specific halogen arrangement facilitates diverse reaction pathways, including Suzuki-Miyaura coupling, Buchwald-Hartwig amination, and nucleophilic aromatic substitution. These reactions are fundamental in constructing active pharmaceutical ingredients (APIs) and novel agrochemical compounds.

  • Pharmaceutical Intermediate: Used in the synthesis of kinase inhibitors and other therapeutic agents requiring pyridine scaffolds.
  • Agrochemical Development: Serves as a precursor for herbicides and pesticides requiring enhanced metabolic stability.
  • Material Science: Applicable in the development of specialized polymers and functional materials.
  • Research and Development: Essential for laboratory-scale exploration of new chemical entities and reaction methodologies.

Quality Assurance and Storage

Quality is paramount in our manufacturing process. Each batch of 3-Bromo-2-chloro-5-fluoropyridine undergoes comprehensive testing using advanced analytical techniques such as HPLC, GC-MS, and NMR spectroscopy. We provide a Certificate of Analysis (COA) with every shipment to verify compliance with stated specifications. Our production facility adheres to strict safety and environmental protocols to minimize risk and ensure product integrity.

For optimal preservation, store this material in a cool, ventilated place away from direct sunlight and moisture. Containers should remain tightly sealed when not in use to prevent degradation or contamination. We recommend handling this compound with appropriate personal protective equipment (PPE) in accordance with standard safety data sheet (SDS) guidelines. Packaging is available in 25 kg drums, with custom packaging solutions available upon request to suit specific logistical requirements.