3-Bromo-2-chloropyridine
- CAS No.52200-48-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Bromo-2-chloropyridine (CAS 52200-48-3), a versatile halogenated pyridine derivative widely used as an intermediate in pharmaceutical and agrochemical synthesis.
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Product Overview
3-Bromo-2-chloropyridine is a key halogenated heterocyclic building block extensively employed in modern organic synthesis. With its dual halogen functionality—bromine at the 3-position and chlorine at the 2-position—this compound offers exceptional regioselectivity for cross-coupling reactions, enabling precise molecular construction in complex active pharmaceutical ingredient (API) development and crop protection chemistry.
Specifications
| Molecular Formula | C₅H₃BrClN |
|---|---|
| Molecular Weight | 192.44 g/mol |
| CAS Number | 52200-48-3 |
| Appearance | White to yellowish crystalline powder |
| Assay (GC) | ≥98.0% |
| Moisture (KF) | ≤0.5% |
| Melting Point | 54–57 °C (lit.) |
| Boiling Point | 219.8 ± 20.0 °C at 760 mmHg |
| Density | 1.7 ± 0.1 g/cm³ |
| Flash Point | 86.8 ± 21.8 °C |
Industrial Applications
As a strategic intermediate, 3-Bromo-2-chloropyridine serves critical roles in multi-step syntheses due to the distinct reactivity of its bromo and chloro substituents. The bromine atom readily participates in palladium-catalyzed Suzuki, Negishi, and Stille couplings, while the chlorine group can be selectively retained or displaced under controlled conditions. This duality makes it invaluable for:
- Pharmaceutical R&D: Synthesis of kinase inhibitors, anti-inflammatory agents, and CNS-targeted therapeutics.
- Agrochemical manufacturing: Construction of novel herbicides and insecticides with enhanced selectivity.
- Functional materials: Development of ligands for catalysis and optoelectronic compounds.
Our product is manufactured under stringent quality control protocols, ensuring batch-to-batch consistency and compliance with international regulatory standards. Standard packaging is 25 kg per fiber drum, with custom options available upon request. Store in a cool, dry, and well-ventilated area away from incompatible materials.
