Intermediates

3-Bromo-2-Fluoro-5-Methylpyridine

  • CAS No.17282-01-8
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 3-Bromo-2-Fluoro-5-Methylpyridine (CAS 17282-01-8) designed for advanced pharmaceutical synthesis. Reliable supply with ≥98.0% purity for global research and production needs.

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Product Technical Details

Product Overview

3-Bromo-2-Fluoro-5-Methylpyridine is a highly specialized fluorinated heterocyclic compound that serves as a critical building block in modern medicinal chemistry and organic synthesis. As a derivative of the pyridine ring system, this compound combines the reactivity of a bromine substituent with the metabolic stability and lipophilicity enhancements provided by the fluorine atom. These characteristics make it an invaluable intermediate for the development of complex pharmaceutical agents and agrochemical formulations.

Our manufacturing process ensures exceptional batch-to-batch consistency, adhering to strict quality control protocols. The presence of the methyl group at the 5-position further diversifies the chemical reactivity, allowing for versatile functionalization in downstream synthesis routes. This product is specifically engineered for research laboratories and industrial production facilities requiring high-performance chemical reagents.

Technical Specifications

ParameterValue
Chemical Name3-Bromo-2-Fluoro-5-Methylpyridine
CAS Number17282-01-8
Molecular FormulaC6H5BrFN
Molecular Weight190.01 g/mol
Purity≥98.0%
AppearanceWhite Crystalline Powder
Density1.6±0.1 g/cm3
Boiling Point207.8±35.0 °C at 760 mmHg
Flash Point79.5±25.9 °C
Refractive Index1.530

Industrial Applications

This fluorinated pyridine derivative is primarily utilized as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs). The bromine atom facilitates cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig couplings, enabling the construction of biaryl structures common in drug candidates. Meanwhile, the fluorine substituent is strategically positioned to influence the binding affinity and pharmacokinetic properties of the final molecule.

Beyond pharmaceuticals, this compound finds applications in the development of advanced materials and agrochemicals. Its stability under various reaction conditions makes it suitable for multi-step synthesis processes where robust intermediates are required. Researchers value this compound for its ability to introduce specific structural motifs that enhance the biological activity of target compounds.

Quality Assurance and Storage

We maintain a rigorous quality assurance system to guarantee the integrity of every shipment. Each batch is accompanied by a Certificate of Analysis (COA) verifying purity and physical properties. The product is packaged in secure 25 kg drums to prevent contamination and moisture absorption during transit.

For optimal stability, store this material in a tightly closed container within a cool, dry, and well-ventilated area. Avoid exposure to direct sunlight and incompatible substances. Proper handling procedures should be followed in accordance with standard laboratory safety guidelines to ensure personnel safety and environmental protection. Our global logistics network ensures timely delivery to support your production schedules.