Intermediates

3-Bromo-2-Fluorobenzaldehyde

  • CAS No.149947-15-9
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 3-Bromo-2-Fluorobenzaldehyde (CAS 149947-15-9) serves as a critical building block for pharmaceutical and agrochemical synthesis, available in bulk quantities with strict QC.

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Product Technical Details

Product Overview

3-Bromo-2-Fluorobenzaldehyde is a highly specialized fluorinated aromatic compound that plays a pivotal role in modern organic synthesis and medicinal chemistry. As a key building block, this substance features a unique substitution pattern on the benzene ring, combining both bromo and fluoro functional groups alongside an aldehyde moiety. This specific arrangement provides chemists with versatile reactivity options, making it an indispensable intermediate for constructing complex molecular architectures found in advanced pharmaceuticals and agrochemicals.

Our manufacturing process ensures that every batch meets rigorous international standards for purity and consistency. We understand that downstream synthesis reactions require precise stoichiometry and minimal impurity profiles. Therefore, our production facilities utilize state-of-the-art purification techniques to guarantee a purity level of 99.0% or higher by gas chromatography. This commitment to quality allows research and development teams to proceed with confidence, knowing that the foundational materials meet the demanding requirements of drug discovery and process chemistry.

Technical Specifications

ParameterSpecification
Chemical Name3-Bromo-2-Fluorobenzaldehyde
CAS Number149947-15-9
Molecular FormulaC7H4BrFO
Molecular Weight203.01 g/mol
AppearanceOff-white or grey crystalline powder
Purity (GC)≥ 99.0%
Melting Point43-46°C
Boiling Point337.5°C
Density1.685 g/cm³
Refractive Index1.584

Industrial Applications

The primary utility of 3-Bromo-2-Fluorobenzaldehyde lies in its capacity to serve as a precursor for various biologically active compounds. The presence of the bromine atom facilitates cross-coupling reactions, such as Suzuki or Heck couplings, while the fluorine atom can enhance metabolic stability and bioavailability in final drug candidates. Consequently, this intermediate is frequently employed in the synthesis of kinase inhibitors, anti-inflammatory agents, and other therapeutic molecules targeting central nervous system disorders.

Beyond pharmaceuticals, this chemical finds application in the agrochemical sector, where fluorinated structures are valued for their enhanced pesticidal activity and environmental persistence profiles. Material science researchers also utilize this compound to develop novel organic polymers and liquid crystals. Our supply chain is optimized to support both small-scale laboratory research and large-scale commercial production, ensuring timely delivery regardless of project scope.

Quality Assurance and Handling

We maintain a robust quality management system that tracks every stage of production from raw material sourcing to final packaging. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing all critical quality attributes. For optimal stability, the product should be stored in a cool, ventilated area away from direct sunlight and moisture. Proper handling procedures should be followed to maintain integrity during transfer and usage. We offer flexible packaging options, including 25 kg drums, and can customize solutions based on specific client logistics requirements.