Intermediates

3-Bromo-4-chlorobenzotrifluoride

  • CAS No.454-78-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 3-Bromo-4-chlorobenzotrifluoride (CAS 454-78-4) designed for pharmaceutical synthesis. Available in bulk with comprehensive COA and global shipping options.

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Product Technical Details

Product Overview

3-Bromo-4-chlorobenzotrifluoride is a highly specialized fluorinated aromatic compound that serves as a critical building block in modern organic synthesis. Characterized by the presence of both bromine and chlorine substituents alongside a robust trifluoromethyl group, this chemical intermediate offers exceptional reactivity for cross-coupling reactions. Our facility produces this compound under strict quality control measures to ensure consistency and reliability for downstream pharmaceutical and agrochemical applications.

The unique structural configuration of this molecule allows chemists to introduce multiple functional groups selectively. The trifluoromethyl moiety enhances metabolic stability and lipophilicity, making it a preferred choice for developing advanced therapeutic agents. As a leading global manufacturer, we prioritize safety and purity in every batch produced.

Key Specifications

ParameterValue
Chemical Name3-Bromo-4-chlorobenzotrifluoride
CAS Number454-78-4
Molecular FormulaC7H3BrClF3
Molecular Weight259.45 g/mol
Purity≥99.0%
AppearanceClear Pale Yellow Liquid

Physical and Chemical Properties

Understanding the physical properties of this intermediate is essential for safe handling and process optimization. The compound exhibits a density of 1.726 g/cm3, indicating a relatively heavy molecular structure typical of halogenated aromatics. Its boiling point ranges between 188 to 190 degrees Celsius, allowing for distillation purification under reduced pressure if required.

The flash point is recorded at 202 degrees Fahrenheit, necessitating standard flammable liquid storage protocols. With a refractive index of 1.499, the material maintains consistent optical properties across batches. The melting point lies between minus 23 and minus 22 degrees Celsius, ensuring it remains liquid at standard ambient temperatures.

Industrial Applications

This fluorinated intermediate is predominantly utilized in the synthesis of complex pharmaceutical active ingredients. It serves as a versatile precursor for creating kinase inhibitors, receptor modulators, and other high-value drug candidates. The dual halogen substitution pattern enables sequential functionalization, providing chemists with flexible synthetic routes.

  • Pharmaceutical intermediate for novel drug discovery
  • Agrochemical synthesis for crop protection agents
  • Material science applications requiring fluorinated aromatics
  • Custom organic synthesis projects

Quality Assurance and Storage

We maintain an rigorous quality assurance program that includes comprehensive testing via GC-MS and NMR spectroscopy. Every shipment is accompanied by a Certificate of Analysis (COA) verifying purity and identity. Packaging is available in various sizes, including 50g and 100g packets, or customized bulk containers based on client requirements.

For optimal stability, store the product in a tightly closed container within a cool, dry, and well-ventilated area. Ensure separation from incompatible substances such as strong oxidizing agents. Adherence to these storage guidelines guarantees the longevity and performance of the chemical in your synthesis processes.