3-Bromo-4-fluorobenzotrifluoride
- CAS No.68322-84-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Bromo-4-fluorobenzotrifluoride (CAS 68322-84-9) is a critical fluorinated building block designed for advanced pharmaceutical synthesis and organic chemistry applications.
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Product Overview
3-Bromo-4-fluorobenzotrifluoride represents a sophisticated fluorinated aromatic compound that serves as a vital intermediate in modern organic synthesis. This chemical structure combines the reactivity of an aryl bromide with the metabolic stability provided by the trifluoromethyl group, making it an indispensable asset for medicinal chemistry programs. Our facility produces this compound under strict quality control standards to ensure consistent performance in downstream reactions.
The presence of both bromine and fluorine substituents on the benzene ring allows for versatile functionalization strategies. Chemists utilize this building block to introduce specific electronic and steric properties into complex molecular architectures. The trifluoromethyl group enhances lipophilicity and metabolic stability, which are crucial parameters in the development of new pharmaceutical agents.
Key Features and Advantages
- High Chemical Purity: Manufactured to exceed 99.0% purity specifications to minimize side reactions.
- Consistent Quality: Every batch undergoes rigorous testing via GC and HPLC to ensure reliability.
- Versatile Reactivity: Suitable for cross-coupling reactions such as Suzuki, Heck, and Buchwald-Hartwig protocols.
- Global Supply Chain: Supported by robust logistics for timely delivery to international laboratories.
- Technical Support: Access to detailed synthesis routes and application guidance from our expert team.
Technical Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 3-Bromo-4-fluorobenzotrifluoride |
| CAS Number | 68322-84-9 |
| Molecular Formula | C7H3BrF4 |
| Molecular Weight | 242.996 g/mol |
| Appearance | Colorless Transparent Liquid |
| Purity | ≥99.0% |
| Boiling Point | 148-149 °C |
| Density | 1.706 g/cm3 |
| Refractive Index | 1.459 |
Industrial Applications
This fluorinated intermediate is primarily utilized in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs). The unique substitution pattern enables the construction of biologically active molecules with improved pharmacokinetic profiles. Additionally, it finds application in agrochemical research where fluorinated compounds are valued for their environmental stability and efficacy.
Research institutions leverage this material for developing novel catalysts and functional materials. The stability of the carbon-fluorine bond ensures that the core structure remains intact during harsh reaction conditions, providing a reliable scaffold for further modification. Our customers rely on this product for scaling up processes from laboratory discovery to pilot plant production.
Storage and Handling
To maintain optimal quality, 3-Bromo-4-fluorobenzotrifluoride should be stored in a tightly closed container within a cool, dry environment. The recommended storage temperature ranges between 0 to 10 degrees Celsius. Proper ventilation is essential when handling this chemical, and standard personal protective equipment including gloves and safety goggles must be worn. Avoid exposure to strong oxidizing agents to prevent unwanted reactions.
Quality Assurance
We are committed to delivering products that meet the highest industry standards. Each shipment is accompanied by a Certificate of Analysis (COA) detailing the specific test results for that batch. Our quality management system ensures traceability and compliance with international regulations. For custom synthesis requirements or bulk pricing inquiries, our sales team is available to provide tailored solutions that meet your specific project needs.
