3-Bromo-4-fluorophenol
- CAS No.27407-11-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Bromo-4-fluorophenol (CAS 27407-11-0), a versatile halogenated aromatic intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
3-Bromo-4-fluorophenol is a high-value halogenated aromatic compound widely employed as a key building block in the synthesis of complex organic molecules. With its dual functionality—featuring both bromo and fluoro substituents on the phenolic ring—it offers excellent regioselectivity for cross-coupling reactions, nucleophilic aromatic substitutions, and directed ortho-metalation strategies. This intermediate is particularly valuable in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals where precise molecular architecture is critical.
Specifications
| Molecular Formula | C6H4BrFO |
|---|---|
| Molecular Weight | 190.998 g/mol |
| CAS Number | 27407-11-0 |
| Appearance | Yellow oil |
| Assay | ≥98.0% |
| Density | 1.8 ± 0.1 g/cm³ |
| Boiling Point | 240.5 ± 20.0 °C at 760 mmHg |
| Flash Point | 99.2 ± 21.8 °C |
| Vapour Pressure | 0.0 ± 0.5 mmHg at 25°C |
| Refractive Index | 1.576 |
Industrial Applications
As a specialized intermediate, 3-Bromo-4-fluorophenol serves as a strategic precursor in multi-step synthetic pathways. Its applications include:
- Construction of biaryl scaffolds via Suzuki-Miyaura or Ullmann couplings
- Synthesis of fluorinated phenolic derivatives for medicinal chemistry programs
- Development of novel ligands and functional materials in materials science
- Preparation of herbicidal and fungicidal agents in crop protection chemistry
Due to its reactivity profile and stability under standard handling conditions, it is well-suited for scale-up in GMP-compliant manufacturing environments. The compound should be stored in a cool, dry, and well-ventilated area away from oxidizing agents and strong bases to maintain integrity and performance.
