3-Bromo-4-methyl-2-pyridinamine
- CAS No.40073-38-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Bromo-4-methyl-2-pyridinamine (CAS 40073-38-9), a key pyridine-based intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
3-Bromo-4-methyl-2-pyridinamine is a high-value pyridine derivative widely employed as a versatile building block in complex organic synthesis. With its dual functional groups—an aromatic amine and a reactive bromine atom—it serves as a strategic scaffold for cross-coupling reactions, heterocyclic elaborations, and the construction of bioactive molecular architectures. This compound is particularly valued in the development of novel pharmaceutical candidates and specialty agrochemicals due to its regioselective reactivity and structural stability.
Specifications
| Molecular Formula | C6H7BrN2 |
|---|---|
| Molecular Weight | 187.037 g/mol |
| Density | 1.6 ± 0.1 g/cm³ |
| Boiling Point | 255.2 ± 35.0 °C at 760 mmHg |
| Flash Point | 108.2 ± 25.9 °C |
| Vapour Pressure | 0.0 ± 0.5 mmHg at 25°C |
| Refractive Index | 1.617 |
| Appearance | Off-white to light yellow crystalline powder |
| Assay | ≥98.0% |
Industrial Applications
As a specialized intermediate, 3-Bromo-4-methyl-2-pyridinamine is primarily utilized in research laboratories and pilot-scale production facilities for the synthesis of complex active pharmaceutical ingredients (APIs) and functional molecules. Its bromo substituent enables efficient palladium-catalyzed transformations such as Suzuki, Buchwald-Hartwig, and Sonogashira couplings, while the amino group facilitates further derivatization or protection strategies. The compound is not intended for direct consumer use but plays a critical role in early-stage drug discovery and process chemistry workflows.
- Ideal for constructing nitrogen-containing heterocycles
- Compatible with modern transition-metal catalysis protocols
- Supplied in high chemical purity to ensure reproducible reaction outcomes
- Stable under standard storage conditions when handled appropriately
Packaged in 25 kg drums or customized containers upon request, this intermediate should be stored in a cool, dry, and well-ventilated area away from incompatible materials. Comprehensive documentation including Certificate of Analysis (COA) and safety data is available to support regulatory compliance and quality assurance in GMP-aligned environments.
