3-Bromo-5-fluorobenzoic acid
- CAS No.176548-70-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Bromo-5-fluorobenzoic acid (CAS 176548-70-2) is a versatile halogenated aromatic intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
3-Bromo-5-fluorobenzoic acid is a high-value halogenated aromatic carboxylic acid widely employed as a key building block in modern organic synthesis. With its dual functionality—featuring both bromo and fluoro substituents at strategic positions on the benzoic acid scaffold—it enables selective cross-coupling reactions, such as Suzuki, Stille, and Buchwald-Hartwig aminations, making it indispensable in the construction of complex molecular architectures.
Specifications
| Molecular Formula | C₇H₄BrFO₂ |
|---|---|
| Molecular Weight | 219.01 g/mol |
| Appearance | White to light yellow powder |
| Assay (Purity) | ≥99.0% |
| Melting Point | 140 °C |
| Boiling Point | 303.3 °C |
| Density | 1.789 g/cm³ |
| Flash Point | 137.3 °C |
| Refractive Index | 1.524 |
Industrial Applications
This compound serves primarily as a specialty intermediate in the development of active pharmaceutical ingredients (APIs), crop protection agents, and functional materials. Its regioselective halogen pattern allows chemists to sequentially introduce diverse functional groups, facilitating modular synthesis strategies in multi-step routes.
- Ideal for palladium-catalyzed C–C and C–N bond-forming reactions
- Enables late-stage diversification in medicinal chemistry programs
- Compatible with standard handling protocols for moisture-sensitive reagents
Stored in a cool, dry, and well-ventilated area away from incompatible substances, 3-Bromo-5-fluorobenzoic acid maintains stability under recommended conditions. Standard packaging is 25 kg per fiber drum, with custom options available upon request to meet global regulatory and logistical requirements.
