Intermediates

3-Bromo-6-chloro-2-methylpyridine

  • CAS No.132606-40-7
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 3-Bromo-6-chloro-2-methylpyridine (CAS 132606-40-7) is a versatile halogenated pyridine intermediate designed for pharmaceutical and agrochemical synthesis. Available in bulk quantities with comprehensive COA support.

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Product Technical Details

Product Overview

3-Bromo-6-chloro-2-methylpyridine represents a critical halogenated heterocyclic building block extensively utilized in modern organic synthesis and industrial chemical manufacturing. As a versatile pyridine derivative, this compound features strategic bromine and chlorine substituents that facilitate diverse cross-coupling reactions, making it indispensable for constructing complex molecular architectures. Our manufacturing process ensures exceptional batch-to-batch consistency, catering to the rigorous demands of research laboratories and large-scale industrial production facilities globally.

The chemical structure provides multiple reactive sites, allowing chemists to selectively functionalize the pyridine ring with high precision. This flexibility is paramount when developing new active pharmaceutical ingredients or advanced agrochemical formulations. The presence of the methyl group further enhances the lipophilicity and reactivity profile of the molecule. We prioritize high purity standards to minimize downstream purification challenges and ensure optimal yield in subsequent synthetic steps.

Technical Specifications

ParameterValue
CAS Number132606-40-7
Molecular FormulaC6H5BrClN
Molecular Weight206.47 g/mol
AppearanceYellow liquid
Purity≥99.0%
Density1.624 g/cm3
Boiling Point220.6ºC at 760 mmHg
Melting Point<40ºC
Flash Point87.2ºC
Refractive Index1.571

Industrial Applications

This intermediate serves as a foundational component across several high-value chemical sectors. In the pharmaceutical industry, it acts as a precursor for synthesizing novel therapeutic agents targeting various biological pathways. The halogen atoms enable palladium-catalyzed coupling reactions such as Suzuki, Heck, or Buchwald-Hartwig aminations, which are standard methodologies in medicinal chemistry.

  • Pharmaceutical Intermediates: Essential for drug discovery and process development.
  • Agrochemical Synthesis: Used in creating advanced pesticide and herbicide formulations.
  • Dye and Pigment Industry: Contributes to the development of stable colorants.
  • Flavor and Fragrance: Utilized in synthesizing specific aromatic compounds.

Quality Assurance and Packaging

Quality control is integral to our production workflow. Each batch undergoes rigorous analytical testing using HPLC and GC-MS to verify identity and purity levels. We provide comprehensive Certificates of Analysis (COA) with every shipment to ensure compliance with your internal specifications. Our standard packaging consists of 25kg drums, designed to maintain product integrity during international transit. Custom packaging solutions are available upon request to accommodate specific logistical requirements.

Storage and Handling Guidelines

To preserve chemical stability, store this material in well-closed, light-resistant, and airtight containers. The compound should be kept in a cool, dry ventilation area away from incompatible substances such as strong oxidizing agents. Proper personal protective equipment including gloves and safety goggles should be worn during handling to prevent skin contact or inhalation. Adhering to these storage protocols ensures the longevity and performance of the chemical in your synthesis processes.