3-Chloro-4-fluoroaniline
- CAS No.367-21-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Chloro-4-fluoroaniline (CAS 367-21-5), a key aromatic amine intermediate for advanced pharmaceutical synthesis.
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Product Overview
3-Chloro-4-fluoroaniline is a high-value aromatic amine widely employed as a critical building block in the synthesis of complex pharmaceutical active ingredients. With its precisely positioned chlorine and fluorine substituents on the aniline ring, this compound offers exceptional regioselectivity and reactivity for downstream coupling and functionalization reactions. Our product is manufactured under stringent quality control protocols to meet the demanding standards of global pharmaceutical and fine chemical industries.
Specifications
| Molecular Formula | C6H5ClFN |
|---|---|
| Molecular Weight | 145.56 g/mol |
| Appearance | White to off-white crystalline solid |
| Purity (GC) | ≥99.0% |
| Single Impurity | ≤0.3% |
| Moisture | ≤0.1% |
| Melting Point | 42–44°C |
| Boiling Point | 227–228°C |
| Density | 1.226 g/cm³ |
| Refractive Index | 1.540–1.542 |
| Flash Point | >230°F |
Industrial Applications
This fluoro-chloro-substituted aniline serves primarily as a strategic intermediate in the multi-step synthesis of targeted therapeutics. It is notably utilized in the production of kinase inhibitors and other oncology-focused small-molecule APIs, where precise halogen placement is essential for biological activity and metabolic stability. Its robust chemical profile makes it ideal for Suzuki, Buchwald-Hartwig, and diazotization reactions in modern medicinal chemistry workflows.
- Manufactured to ≥99.0% purity with tightly controlled impurity profiles
- Consistent batch-to-batch quality supported by full analytical documentation
- Available in standard 25 kg drums or customized packaging upon request
- Stored and shipped under cool, dry, and well-ventilated conditions to ensure stability
