3-Chloro-4-fluoronitrobenzene
- CAS No.350-30-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Chloro-4-fluoronitrobenzene (CAS 350-30-1), a key aromatic intermediate for fluoroquinolone and tyrosine kinase inhibitor APIs.
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Product Overview
3-Chloro-4-fluoronitrobenzene is a high-value aromatic halogenated nitro compound widely employed as a critical building block in the synthesis of advanced pharmaceutical active ingredients. With its precisely positioned chlorine and fluorine substituents adjacent to the electron-withdrawing nitro group, this molecule offers exceptional regioselectivity for nucleophilic aromatic substitution reactions, making it indispensable in modern medicinal chemistry workflows.
Specifications
| Molecular Formula | C6H3ClFNO2 |
|---|---|
| Molecular Weight | 175.545 g/mol |
| CAS Number | 350-30-1 |
| Appearance | White to light yellow crystalline powder |
| Assay | ≥99.0% |
| Melting Point | 40–42 °C (lit.) |
| Boiling Point | 232.5 ± 20.0 °C at 760 mmHg |
| Density | 1.5 ± 0.1 g/cm³ |
| Flash Point | 94.4 ± 21.8 °C |
| Vapour Pressure | 0.1 ± 0.4 mmHg at 25 °C |
| Refractive Index | 1.555 |
Industrial Applications
This compound serves as a strategic intermediate in the multi-step synthesis of several important therapeutic agents, including:
- Neratinib (CAS 698387-09-6), a tyrosine kinase inhibitor used in oncology,
- Norfloxacin (CAS 70458-96-7) and Ciprofloxacin (CAS 85721-33-1), broad-spectrum fluoroquinolone antibiotics.
Its dual halogen functionality enables sequential cross-coupling or displacement reactions, facilitating the construction of complex heterocyclic scaffolds under controlled conditions. As a non-application-ready chemical entity, it is strictly intended for use in authorized pharmaceutical manufacturing and R&D settings.
Handling and Storage
Store in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. Keep container tightly closed when not in use. Supplied in 25 kg fiber drums, with custom packaging available upon request to meet global regulatory and logistical requirements.
