3-Chloro-5-fluorobenzonitrile
- CAS No.327056-73-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Chloro-5-fluorobenzonitrile (CAS 327056-73-5), a key fluorinated aromatic intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
3-Chloro-5-fluorobenzonitrile is a high-value fluorinated aromatic building block widely employed in the synthesis of complex organic molecules. With its dual halogen substitution pattern—chloro at the meta-position and fluoro at the para-position relative to the nitrile group—it offers excellent regioselectivity for cross-coupling reactions, nucleophilic aromatic substitutions, and heterocycle formations. This compound serves as a critical intermediate in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals, where precise molecular architecture and metabolic stability are paramount.
Specifications
| Molecular Formula | C₇H₃ClFN |
|---|---|
| Molecular Weight | 155.56 g/mol |
| CAS Number | 327056-73-5 |
| Appearance | White crystalline powder |
| Assay | ≥98.0% |
| Melting Point | 54–59 °C (lit.) |
| Boiling Point | 195.0 ± 20.0 °C at 760 mmHg |
| Density | 1.3 ± 0.1 g/cm³ |
| Flash Point | 71.7 ± 21.8 °C |
| Vapour Pressure | 0.4 ± 0.4 mmHg at 25 °C |
| Refractive Index | 1.537 |
Industrial Applications
As a versatile synthetic intermediate, 3-Chloro-5-fluorobenzonitrile is primarily utilized in multi-step organic syntheses requiring robust aromatic scaffolds with orthogonal reactivity. Its applications include:
- Serving as a precursor in the construction of biologically active triazole, pyridine, and quinoline derivatives.
- Enabling Suzuki, Buchwald-Hartwig, and other palladium-catalyzed transformations due to its activated aryl halide sites.
- Supporting the development of novel crop protection agents and veterinary pharmaceuticals through tailored functionalization.
Stored in a cool, well-ventilated area away from incompatible materials, this intermediate is typically supplied in 25 kg drums or customized packaging to meet global regulatory and logistical standards.
