3-Chloro-5-fluoropyridine
- CAS No.514797-99-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Chloro-5-fluoropyridine (CAS 514797-99-0), a key fluorinated heterocyclic intermediate for advanced pharmaceutical synthesis.
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Product Overview
3-Chloro-5-fluoropyridine is a versatile fluorinated heterocyclic compound widely employed as a critical building block in the synthesis of complex pharmaceutical active pharmaceutical ingredients (APIs). With its unique combination of chlorine and fluorine substituents at the 3- and 5-positions of the pyridine ring, this molecule offers excellent reactivity for cross-coupling, nucleophilic substitution, and functional group interconversion reactions. Our product is manufactured under stringent quality control protocols to ensure consistent performance in demanding medicinal chemistry and process development environments.
Specifications
| Molecular Formula | C₅H₃ClFN |
|---|---|
| Molecular Weight | 131.54 g/mol |
| CAS Number | 514797-99-0 |
| Appearance | Yellow liquid |
| Purity | ≥98.0% (GC or HPLC) |
| Density | 1.3 ± 0.1 g/cm³ |
| Boiling Point | 126.1 ± 20.0 °C at 760 mmHg |
| Flash Point | 51.9 ± 21.8 °C |
| Refractive Index | 1.503 |
Industrial Applications
As a specialty halogenated pyridine derivative, 3-Chloro-5-fluoropyridine serves primarily as an advanced intermediate in the pharmaceutical industry. Its dual halogen functionality enables sequential and selective transformations, making it invaluable in the construction of structurally diverse drug candidates targeting neurological, oncological, and metabolic disorders. The compound is also utilized in agrochemical research for the development of novel crop protection agents.
- Enables precise regioselective functionalization in multi-step syntheses
- Compatible with modern catalytic systems including Pd-, Cu-, and Ni-mediated couplings
- Supplied in industrial-scale packaging with full analytical documentation (COA, MSDS)
- Stored under cool, dry conditions in tightly sealed containers to maintain stability
