3-Chlorobenzyl cyanide
- CAS No.1529-41-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Chlorobenzyl cyanide (CAS 1529-41-5) for pharmaceutical intermediate synthesis, ensuring optimal yield in Lorazepam production with ≥99.0% assay.
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Product Overview
3-Chlorobenzyl cyanide (CAS 1529-41-5) is a critical aromatic nitrile compound widely utilized as a building block in advanced pharmaceutical synthesis. This colorless transparent liquid exhibits excellent reactivity due to its electron-withdrawing chloro and cyano functional groups, enabling efficient nucleophilic substitution and condensation reactions. With a molecular formula of C8H6ClN and molecular weight of 151.593 g/mol, it serves as a pivotal precursor in the production of benzodiazepine derivatives. Its stability profile requires careful handling away from strong acids, bases, oxidizing and reducing agents to maintain structural integrity during industrial processing.
Specifications
Our premium-grade 3-Chlorobenzyl cyanide undergoes rigorous quality control to meet stringent pharmaceutical manufacturing standards. Key physicochemical properties are verified through advanced analytical techniques including GC-MS and NMR spectroscopy. The comprehensive specification profile ensures batch-to-batch consistency for reliable scale-up operations.
| Density | 1.2±0.1 g/cm³ |
|---|---|
| Boiling Point | 270.0±0.0 °C at 760 mmHg |
| Melting Point | 11-13 °C (lit.) |
| Assay | ≥99.0% |
| Water Content | ≤0.5% |
| Flash Point | 107.7±15.4 °C |
| LogP | 2.04 |
Applications
Primarily employed as a key intermediate in the synthesis of Lorazepam (CAS 846-49-1), this compound enables the construction of the benzodiazepine core structure through controlled alkylation and cyclization steps. Its strategic chloro substitution facilitates regioselective reactions critical for achieving high-purity active pharmaceutical ingredients. Additional applications include:
- Synthesis of anticonvulsant and anxiolytic drug candidates
- Production of specialty agrochemical intermediates
- Development of novel heterocyclic compounds for medicinal chemistry research
The compound's compatibility with modern flow chemistry systems enhances its utility in continuous manufacturing processes, reducing waste and improving overall process economics for pharmaceutical manufacturers.
Packaging & Storage
Supplied in 25kg HDPE drums with nitrogen-purged headspace to prevent moisture ingress and oxidation. Custom packaging configurations are available to meet specific client requirements including IBC totes and small-scale research quantities. Store in a cool, dry, well-ventilated area below 25°C with containers tightly sealed. Implement standard industrial hygiene practices including chemical-resistant gloves and eye protection during handling to ensure workplace safety. Shelf life exceeds 24 months when stored under recommended conditions with periodic quality verification through our certified COA documentation.
