3-Chloromethyl-benzotrifluoride
- CAS No.705-29-3
- GradeIndustrial / Pharmaceutical
- Availabilityβ In Stock
High-purity 3-Chloromethyl-benzotrifluoride (CAS 705-29-3) is a vital fluorinated intermediate for pharmaceutical and agrochemical synthesis.
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Product Overview
3-Chloromethyl-benzotrifluoride, also known by its systematic name 1-(chloromethyl)-3-(trifluoromethyl)benzene, stands as a pivotal fluorinated organic intermediate in modern chemical synthesis. This compound features a benzene ring substituted with both a chloromethyl group and a trifluoromethyl group at the meta position, imparting unique reactivity and stability profiles essential for complex molecular construction. As a key building block, it facilitates the introduction of fluorine atoms into organic frameworks, significantly enhancing the metabolic stability and lipophilicity of downstream pharmaceutical and agrochemical products.
Our manufacturing facility produces this chemical under strict quality control protocols to ensure consistent batch-to-burity. The presence of the trifluoromethyl moiety makes this intermediate highly valuable in medicinal chemistry, where fluorine substitution is often employed to improve drug bioavailability and binding affinity. We supply this material globally to research institutions and industrial partners who require reliable sources of high-performance fluorinated synthons.
Technical Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | 3-Chloromethyl-benzotrifluoride |
| CAS Number | 705-29-3 |
| Molecular Formula | C8H6ClF3 |
| Molecular Weight | 194.58 g/mol |
| Appearance | Colorless clear liquid |
| Purity (Assay) | ≥98.0% |
| Density | 1.254 g/cm3 |
| Boiling Point | 180-182°C |
| Refractive Index | 1.464 |
Industrial Applications
This fluorinated intermediate serves as a versatile precursor in the synthesis of various high-value compounds. Its primary application lies in the pharmaceutical industry, where it is utilized to construct active pharmaceutical ingredients (APIs) requiring meta-substituted trifluoromethyl benzene structures. The chloromethyl group offers a reactive handle for nucleophilic substitution reactions, allowing chemists to attach diverse functional groups efficiently.
Beyond pharmaceuticals, 3-Chloromethyl-benzotrifluoride finds utility in agrochemical development, particularly in the creation of novel herbicides and pesticides where fluorine content enhances environmental stability. Additionally, it is employed in the production of advanced polymers and liquid crystals, where specific electronic properties are required. Our technical team supports clients in optimizing synthesis routes to maximize yield and minimize waste during scale-up processes.
Quality Assurance And Safety
We adhere to rigorous quality management systems to guarantee the integrity of every shipment. Each batch undergoes comprehensive analysis using Gas Chromatography (GC) and other validated methods to confirm purity levels meet or exceed the stated specification of 98.0%. A Certificate of Analysis (COA) is provided with every order, detailing test results and ensuring full traceability.
Regarding safety, this compound should be handled with appropriate personal protective equipment, including chemical-resistant gloves and eye protection. It must be stored in a cool, ventilated area away from incompatible materials such as strong oxidizing agents. Our packaging options include 200 kg drums or custom configurations based on client logistics requirements. We are committed to delivering not only premium chemicals but also reliable technical support and safe global shipping solutions for all our partners.
