3-Cyano-2-fluorobenzoic acid
- CAS No.219519-77-4
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Cyano-2-fluorobenzoic acid (CAS 219519-77-4) designed for advanced organic synthesis and pharmaceutical intermediate applications.
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Product Overview
3-Cyano-2-fluorobenzoic acid is a specialized fluorinated aromatic compound that serves as a critical building block in modern medicinal chemistry and agrochemical development. This molecule features a unique substitution pattern where both cyano and fluoro groups are positioned ortho and meta to the carboxylic acid functionality, respectively. Such structural arrangement imparts distinct electronic properties that facilitate diverse downstream transformations. Our facility produces this compound under strict quality control protocols to ensure consistency for large-scale industrial applications.
The presence of the fluorine atom enhances metabolic stability and lipophilicity in final drug candidates, making this intermediate highly valuable for pharmaceutical research. Additionally, the cyano group offers a versatile handle for further functionalization through hydrolysis, reduction, or coupling reactions. We supply this material to global partners who require reliable sources of high-performance chemical intermediates for complex synthesis routes.
Chemical Properties and Specifications
Understanding the physicochemical characteristics of 3-Cyano-2-fluorobenzoic acid is essential for process chemists designing reaction conditions. The compound exhibits high thermal stability and specific solubility profiles suitable for various organic solvents. Below are the key technical parameters verified through our analytical laboratories.
| Parameter | Value |
|---|---|
| Chemical Name | 3-Cyano-2-fluorobenzoic acid |
| CAS Number | 219519-77-4 |
| Molecular Formula | C8H4FNO2 |
| Molecular Weight | 165.12 g/mol |
| Appearance | White powder |
| Purity | ≥99.0% |
| Density | 1.425 g/cm3 |
| Boiling Point | 313.532°C |
| Flash Point | 143.419°C |
| Refractive Index | 1.565 |
Industrial Applications
This fluorinated benzoic acid derivative is primarily utilized as an intermediate in the synthesis of active pharmaceutical ingredients (APIs). The electron-withdrawing nature of the substituents activates the aromatic ring for nucleophilic aromatic substitution reactions. Chemists frequently employ this building block in the construction of kinase inhibitors and other targeted therapeutics where fluorine substitution is known to improve binding affinity.
Beyond pharmaceuticals, the compound finds utility in the development of advanced agrochemicals and functional materials. Its stability under various reaction conditions allows for robust manufacturing processes. We support clients in scaling up from laboratory research to commercial production by providing consistent batch quality and comprehensive technical documentation.
Quality Assurance and Storage
Every batch of 3-Cyano-2-fluorobenzoic acid undergoes rigorous testing using high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy. We provide a Certificate of Analysis (COA) with each shipment to verify compliance with specified purity standards. Proper storage is crucial to maintain product integrity over time.
- Store in a cool, ventilated place away from direct sunlight.
- Keep containers tightly closed when not in use to prevent moisture absorption.
- Avoid contact with strong oxidizing agents or incompatible bases.
- Follow standard laboratory safety procedures during handling and weighing.
Our commitment to excellence ensures that clients receive materials that meet the demanding requirements of modern chemical synthesis. For custom packaging or specific purity grades, please contact our sales team for detailed discussions regarding your project needs.
