Intermediates

3'-Deoxy-3'-fluoro Thymidine

  • CAS No.25526-93-6
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 3'-Deoxy-3'-fluoro Thymidine (CAS 25526-93-6) for pharmaceutical research. ≥98% assay, global shipping, and full COA support available for bulk orders.

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Product Technical Details

Product Overview

3'-Deoxy-3'-fluoro Thymidine represents a critical fluorinated nucleoside analog utilized extensively within the pharmaceutical industry for advanced medicinal chemistry research. As a specialized building block, this compound features a strategic fluorine substitution at the 3' position of the sugar moiety, which significantly alters its metabolic stability and biological activity compared to natural nucleosides. Our facility produces this high-purity intermediate under strict quality control protocols to support global drug discovery programs and complex organic synthesis workflows.

The introduction of fluorine into nucleoside structures is a well-established strategy in modern drug design to enhance binding affinity and resist enzymatic degradation. Consequently, this material serves as a vital precursor for developing novel therapeutic agents targeting viral replication mechanisms. Researchers rely on the consistent quality of our supply to ensure reproducible results in structure-activity relationship studies and preclinical evaluations. We are committed to providing reliable chemical solutions that accelerate the development of next-generation antiviral therapies.

Technical Specifications

ParameterValue
Chemical Name3'-Deoxy-3'-fluoro Thymidine
CAS Number25526-93-6
Molecular FormulaC10H13FN2O4
Molecular Weight244.22 g/mol
AppearanceWhite to off-white powder
Assay (HPLC)≥98.0%
Loss on Drying≤0.5%
Melting Point176-178ºC
Density1.44 g/cm³

Industrial Applications

This fluorinated nucleoside is primarily employed as a key intermediate in the synthesis of antiviral pharmaceutical agents. Its unique chemical structure allows for specific interactions with viral polymerases, making it an invaluable tool in the design of inhibitors. Beyond antiviral research, it is also utilized in biochemical assays to study nucleoside metabolism and enzyme kinetics. Our customers include leading pharmaceutical companies, contract research organizations, and academic institutions focused on infectious disease treatments.

We understand the stringent requirements of pharmaceutical synthesis. Therefore, every batch undergoes rigorous analytical testing using high-performance liquid chromatography and nuclear magnetic resonance spectroscopy. This ensures that the chemical identity and purity levels meet or exceed the specifications required for complex organic synthesis workflows. Our technical team is available to provide support on handling and integration into your specific production processes.

Quality Assurance and Storage

Quality is paramount in the production of fine chemicals. Our manufacturing process adheres to international standards to minimize impurities and ensure batch-to-batch consistency. Each shipment is accompanied by a comprehensive Certificate of Analysis detailing all critical quality attributes. Regarding logistics, we offer flexible packaging solutions including standard 25 kg drums or customized containers based on specific project needs.

Proper storage in a cool, ventilated environment maintains the integrity of the product over extended periods. The material should be kept away from direct sunlight and moisture to prevent degradation. Our global supply chain ensures timely delivery to research laboratories and manufacturing sites worldwide. For large-scale requirements, we offer competitive bulk pricing and can discuss custom synthesis routes to meet specific purity profiles or derivative needs.