Intermediates

3-(Difluoromethoxy)aniline

  • CAS No.22236-08-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 3-(Difluoromethoxy)aniline (CAS 22236-08-4) designed for advanced organic synthesis. Reliable supply with strict quality control for pharmaceutical and agrochemical intermediates.

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Product Technical Details

Product Overview

3-(Difluoromethoxy)aniline represents a specialized fluorinated aromatic amine essential for modern organic synthesis pathways and medicinal chemistry research. As a key building block, this compound facilitates the strategic introduction of the difluoromethoxy group into complex molecular structures, significantly enhancing metabolic stability and lipophilicity in target molecules. Our manufacturing process ensures high purity levels suitable for demanding research and industrial applications where consistency is paramount. We adhere to strict quality management systems to guarantee batch-to-batch reliability for our global partners. This chemical serves as a vital component in the development of next-generation therapeutic agents and advanced materials.

Technical Specifications

ParameterValue
CAS Number22236-08-4
Molecular FormulaC7H7F2NO
Molecular Weight159.133
AppearanceColorless transparent liquid
Assay≥98.0%
Packing200 kg/drum or customized

Physical and Chemical Properties

The physicochemical profile of 3-(Difluoromethoxy)aniline is characterized by specific stability parameters crucial for safe handling and storage protocols. The compound exhibits a density of approximately 1.3 g/cm3 with a boiling point around 230.1 degrees Celsius at standard pressure. Its flash point is recorded at 92.9 degrees Celsius, indicating necessary safety precautions during thermal processing and distillation. The refractive index of 1.502 confirms the optical purity of the substance. These properties make it compatible with various reaction conditions typically found in pharmaceutical and agrochemical development laboratories. Low vapor pressure ensures minimal evaporation loss during standard operations.

Industrial Applications

Primarily utilized as an intermediate in organic synthesis, this fluorinated aniline derivative serves as a precursor for numerous high-value chemicals and complex architectures. It is extensively employed in the development of novel pharmaceutical agents where fluorine substitution is required to improve bioavailability and binding affinity. Additionally, it finds application in the synthesis of advanced agrochemicals and functional materials requiring specific electronic properties. Researchers value this compound for its reactivity profile, which allows for versatile coupling reactions and functional group transformations including nucleophilic substitutions. Our supply supports scale-up from laboratory research to pilot plant production ensuring seamless transition during process development.

Quality Assurance and Safety

We prioritize product safety and regulatory compliance throughout our entire supply chain network. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) and Material Safety Data Sheet (MSDS) to ensure safe handling protocols are followed strictly. Storage recommendations include keeping the container in a cool, ventilated area away from incompatible substances and direct sunlight. Packaging options include standard 200 kg drums or customized solutions based on client logistical requirements and regional regulations. Our technical team provides ongoing support to optimize usage efficiency and maintain safety standards in your facility. All products are tested using advanced chromatography methods to verify purity specifications.