3-(Difluoromethoxy)nitrobenzene
- CAS No.22236-07-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-(Difluoromethoxy)nitrobenzene (CAS 22236-07-3), a key fluorinated aromatic intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
3-(Difluoromethoxy)nitrobenzene is a high-value fluorinated aromatic compound widely employed as a versatile building block in modern organic synthesis. With its unique combination of an electron-withdrawing nitro group and a metabolically stable difluoromethoxy moiety, this intermediate plays a critical role in the development of complex molecules for pharmaceuticals, crop protection agents, and specialty materials. Our product is manufactured under stringent quality control protocols to ensure consistent performance and reliability for industrial-scale applications.
Specifications
| Molecular Formula | C₇H₅F₂NO₃ |
|---|---|
| Molecular Weight | 189.116 g/mol |
| CAS Number | 22236-07-3 |
| Appearance | Light yellow transparent liquid |
| Assay | ≥98.0% |
| Density | 1.4 ± 0.1 g/cm³ |
| Boiling Point | 250.6 ± 30.0 °C at 760 mmHg |
| Flash Point | 105.3 ± 24.6 °C |
| Vapour Pressure | 0.0 ± 0.5 mmHg at 25 °C |
| Refractive Index | 1.494 |
Industrial Applications
As a specialized fluoroaromatic intermediate, 3-(Difluoromethoxy)nitrobenzene serves as a strategic precursor in multi-step synthetic routes targeting bioactive molecules. Its primary utility lies in:
- Enabling the construction of difluoromethoxy-substituted anilines after nitro-group reduction, which are prevalent motifs in medicinal chemistry.
- Facilitating cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to access structurally diverse scaffolds for drug discovery programs.
- Serving as a key synthon in the production of novel agrochemicals requiring enhanced lipophilicity and metabolic stability.
Stored in a cool, well-ventilated area away from ignition sources, this compound is typically supplied in 200 kg drums or customized packaging to meet client logistics requirements. As a non-application-ready chemical, it is intended exclusively for use as a synthesis intermediate by qualified professionals in controlled laboratory or manufacturing environments.
