Intermediates

3-Ethoxy-4-methoxybenzaldehyde

  • CAS No.1131-52-8
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 3-Ethoxy-4-methoxybenzaldehyde (CAS 1131-52-8) supplied for pharmaceutical synthesis. Ideal intermediate for Apremilast and PDE4 inhibitor production with strict quality control.

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Product Technical Details

Product Overview

3-Ethoxy-4-methoxybenzaldehyde represents a vital class of substituted aromatic aldehydes extensively utilized within the pharmaceutical and fine chemical industries. As a key building block, this compound facilitates the construction of complex molecular architectures required for modern therapeutic agents. Our manufacturing process ensures exceptional purity levels, making it an ideal candidate for sensitive organic synthesis reactions where impurity profiles must be strictly controlled to meet regulatory standards.

This specialized chemical features a unique substitution pattern on the benzene ring, providing distinct reactivity characteristics that are highly valued in multi-step synthesis pathways. The presence of both ethoxy and methoxy groups enhances its solubility profile and stability during various reaction conditions, allowing chemists to achieve higher yields in downstream processes.

Technical Specifications

ParameterValue
CAS Number1131-52-8
Molecular FormulaC10H12O3
Molecular Weight180.201
AppearanceWhite to yellow crystals
Assay≥99.0%
Melting Point51 °C
Boiling Point289.4±20.0 °C at 760 mmHg
Density1.1±0.1 g/cm3
Loss on Drying≤0.5%

Industrial Applications

In terms of therapeutic applications, this intermediate plays a pivotal role in the synthesis of Apremilast, a well-known therapeutic agent used in the management of psoriasis and psoriatic arthritis. The high purity of our supplied material ensures that the final active pharmaceutical ingredient meets stringent safety and efficacy requirements necessary for patient care.

Furthermore, its chemical structure allows for versatility in developing phosphodiesterase type 4 (PDE4) inhibitors, which are critical in inflammatory disease research. Researchers also utilize this aldehyde in the preparation of berberine analogues, exploring their potential as LDL-receptor upregulators for cardiovascular health. These diverse applications highlight the compound's significance in both established drug manufacturing and emerging biomedical research.

Quality Assurance and Handling

Our facility adheres to strict quality management systems to guarantee consistency across every batch. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing physical and chemical properties. We employ advanced analytical methods, including HPLC and GC, to verify assay purity and identify any potential impurities.

For packaging, we offer standard 25kg drums designed to protect the material from moisture and light during transit. Custom packaging solutions are available upon request to suit specific logistical needs. Storage recommendations include keeping the container tightly closed in a cool, dry, and well-ventilated place to maintain stability over extended periods. Proper handling procedures should be followed to ensure safety during laboratory or industrial use.