Intermediates

3-Oxetanone

  • CAS No.6704-31-0
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

3-Oxetanone (CAS 6704-31-0) is a versatile cyclic ketone intermediate widely used in pharmaceutical R&D and advanced organic synthesis.

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Product Technical Details

Product Overview

3-Oxetanone is a highly reactive four-membered cyclic ketone with the molecular formula C₃H₄O₂ and a molecular weight of 72.06 g/mol. As a strained heterocyclic compound containing both an ether linkage and a carbonyl group, it serves as a valuable building block in medicinal chemistry and synthetic organic laboratories. Its unique ring strain and bifunctional reactivity enable diverse transformations, making it particularly useful in the construction of complex molecular architectures found in modern pharmaceutical candidates.

Specifications

Molecular FormulaC₃H₄O₂
Molecular Weight72.06 g/mol
Density1.231 g/mL at 20 °C (lit.)
Boiling Point140 °C
Flash Point53 °C

Industrial Applications

This specialty intermediate is primarily employed in research and development settings for the synthesis of bioactive molecules, including potential neurological therapeutics and complex pharmaceutical APIs. Due to its electrophilic carbonyl and strained oxetane ring, 3-oxetanone participates in nucleophilic ring-opening reactions, cycloadditions, and serves as a precursor to functionalized alcohols, esters, and amino derivatives. Key application areas include:

  • Pharmaceutical research for scaffold diversification
  • Synthesis of fluorinated analogs when combined with fluorochemical platforms
  • Development of novel agrochemical intermediates
  • Preparation of high-value heterocyclic building blocks

As a non-controlled, non-narcotic chemical entity, 3-oxetanone is compliant with international regulatory standards for laboratory and industrial use under appropriate safety protocols.