3-(Trifluoromethyl)benzonitrile
- CAS No.368-77-4
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-(Trifluoromethyl)benzonitrile (CAS 368-77-4) designed for advanced organic synthesis and pharmaceutical intermediate applications.
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Product Overview
3-(Trifluoromethyl)benzonitrile is a highly valued fluorinated organic intermediate widely utilized in the synthesis of complex pharmaceutical compounds and agrochemical agents. As a key building block, this compound features a robust benzotrifluoride structure combined with a reactive nitrile group, offering versatile chemical functionality for downstream derivatization. The introduction of the trifluoromethyl group significantly enhances the metabolic stability and lipophilicity of final drug candidates, making this intermediate essential in modern medicinal chemistry programs.
Our manufacturing process ensures consistent quality and high purity levels suitable for demanding research and industrial scale production. We adhere to strict quality control protocols to guarantee that every batch meets international standards for organic synthesis materials. This product serves as a critical precursor in the development of novel therapeutic molecules, particularly where fluorine substitution is required to optimize pharmacokinetic properties.
Key Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 3-(Trifluoromethyl)benzonitrile |
| CAS Number | 368-77-4 |
| Molecular Formula | C8H4F3N |
| Molecular Weight | 171.119 g/mol |
| Appearance | Colorless liquid |
| Assay | ≥98.0% |
| Boiling Point | 189.0±35.0 °C at 760 mmHg |
| Melting Point | 16-20 °C |
| Density | 1.3±0.1 g/cm3 |
| Refractive Index | 1.461 |
| Flash Point | 72.2±0.0 °C |
| Storage Condition | 2-8°C |
Industrial Applications
This fluorinated nitrile derivative is primarily employed as a strategic intermediate in the multistep synthesis of active pharmaceutical ingredients (APIs). The nitrile functionality allows for various transformations, including hydrolysis to carboxylic acids, reduction to amines, or conversion into heterocyclic structures. Consequently, it is frequently utilized in the production of kinase inhibitors, receptor modulators, and other targeted therapies where precise molecular architecture is paramount.
Beyond pharmaceuticals, this compound finds application in the agrochemical sector for the development of advanced pesticides and herbicides. The stability provided by the trifluoromethyl moiety ensures longevity and efficacy in field conditions. Researchers also leverage this building block in material science for creating specialized polymers and liquid crystals with enhanced thermal and chemical resistance properties.
Quality Assurance and Storage
We maintain a comprehensive quality management system to ensure product integrity from synthesis to delivery. Each shipment is accompanied by a Certificate of Analysis (COA) detailing batch-specific test results. Our facility employs advanced analytical techniques such as HPLC and GC-MS to verify purity and identify impurities at trace levels.
- Packaged in 200 kg drums or customized containers based on client requirements.
- Store in a cool, ventilated place away from direct sunlight and heat sources.
- Keep containers tightly closed when not in use to prevent moisture absorption.
- Handle with appropriate personal protective equipment during transfer and processing.
- Global shipping available with compliant documentation for hazardous materials.
For technical inquiries or custom synthesis requests regarding 3-(Trifluoromethyl)benzonitrile, our expert team is ready to provide support tailored to your specific project needs. We are committed to being a reliable partner in your supply chain.
