3-(Trifluoromethyl)benzoyl chloride
- CAS No.2251-65-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity 3-(Trifluoromethyl)benzoyl chloride (CAS 2251-65-2) designed for advanced organic synthesis. Reliable bulk supply with comprehensive quality documentation.
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Product Overview
3-(Trifluoromethyl)benzoyl chloride is a highly versatile fluorinated organic intermediate that plays a critical role in modern chemical synthesis. Characterized by the presence of a trifluoromethyl group at the meta position of the benzoyl chloride structure, this compound offers unique electronic and steric properties that enhance the biological activity and metabolic stability of downstream molecules. As a key building block, it is extensively utilized in the construction of complex pharmaceutical architectures, agrochemical formulations, and advanced material sciences.
Our manufacturing process ensures exceptional consistency and purity, making this reagent an ideal choice for research and development teams as well as large-scale industrial production. The introduction of the trifluoromethyl moiety is often a strategic step in medicinal chemistry to improve lipophilicity and bioavailability. We adhere to strict quality control protocols to guarantee that every batch meets the rigorous demands of global chemical standards.
Key Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | 3-(Trifluoromethyl)benzoyl chloride |
| CAS Number | 2251-65-2 |
| Molecular Formula | C8H4ClF3O |
| Molecular Weight | 208.565 g/mol |
| Appearance | Colorless to light yellow transparent liquid |
| Assay (Purity) | ≥98.0% |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 185.5±0.0 °C at 760 mmHg |
| Vapour Pressure | 0.7±0.3 mmHg at 25°C |
| Index of Refraction | 1.467 |
Industrial Applications
This fluorinated acyl chloride serves as a fundamental electrophilic reagent in various organic transformations. Its primary application lies in the synthesis of pharmaceutical intermediates where the trifluoromethyl group is required to modulate the pharmacokinetic properties of the final active ingredient. Additionally, it is employed in the production of agrochemicals to enhance environmental stability and efficacy.
- Pharmaceutical API Synthesis: Used as a coupling agent in the formation of amides and esters.
- Agrochemical Development: Integral component in creating robust pesticide and herbicide structures.
- Material Science: Utilized in the modification of polymers to introduce fluorine content.
- Research and Development: Essential building block for novel organic compound exploration.
Storage and Handling
To maintain optimal quality and safety, 3-(Trifluoromethyl)benzoyl chloride should be stored in a cool, ventilated place away from direct sunlight and moisture. As an acyl chloride, it is sensitive to hydrolysis and should be kept in tightly sealed containers under inert atmosphere conditions if possible. Proper personal protective equipment must be worn during handling to prevent exposure to skin and eyes. We offer flexible packaging options, including 200 kg drums, and can customize packaging according to specific customer requirements to ensure safe global transportation. Each shipment is accompanied by a Certificate of Analysis (COA) to verify compliance with stated specifications.
