3,5-Difluoropyridine-4-carboxylic acid
- CAS No.903522-29-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3,5-Difluoropyridine-4-carboxylic acid (≥99.0%) for advanced pharmaceutical synthesis. Reliable intermediate with consistent quality and global supply.
Request Bulk PricingProduct Technical Details
Product Overview
3,5-Difluoropyridine-4-carboxylic acid is a high-value fluorinated heterocyclic carboxylic acid widely employed as a key building block in modern medicinal chemistry. With its dual fluorine substitution pattern and carboxylic acid functionality at the 4-position of the pyridine ring, this compound offers exceptional reactivity and selectivity in cross-coupling, amidation, and derivatization reactions. It serves as a critical intermediate in the synthesis of complex pharmaceutical active ingredients targeting diverse therapeutic areas.
Specifications
| CAS Number | 903522-29-2 |
|---|---|
| Molecular Formula | C6H3F2NO2 |
| Molecular Weight | 159.09 g/mol |
| Appearance | Yellow liquid |
| Purity | ≥99.0% |
| Density | 1.535 g/cm³ |
| Boiling Point | 316.9°C at 760 mmHg |
| Flash Point | 145.5°C |
| Refractive Index | 1.515 |
Industrial Applications
This fluorinated pyridine derivative is primarily utilized in the pharmaceutical industry as a versatile synthetic intermediate. Its unique electronic and steric properties enable the construction of structurally complex molecules with improved metabolic stability, bioavailability, and target affinity. Common applications include:
- Synthesis of kinase inhibitors and other targeted oncology therapeutics
- Development of central nervous system (CNS) agents requiring enhanced blood-brain barrier penetration
- Preparation of anti-infective scaffolds leveraging fluorine’s influence on lipophilicity
- Building block for agrochemical research and specialty materials
Stored in tightly sealed containers under cool, dry conditions, 3,5-Difluoropyridine-4-carboxylic acid maintains stability during standard handling and transportation. Supplied in 25 kg drums for industrial-scale manufacturing, it meets stringent quality control standards required by global regulatory frameworks.
