4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile
- CAS No.906673-45-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity pharmaceutical intermediate for Crisaborole synthesis. Available in bulk quantities with full COA and regulatory support.
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Product Overview
4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile is a specialized organic compound serving as a critical building block in the pharmaceutical industry. Primarily recognized for its role in the synthesis of Crisaborole (AN2728), this intermediate facilitates the production of non-steroidal topical treatments for inflammatory skin conditions. Our manufacturing process ensures high chemical integrity, making it an essential component for research and development teams focused on dermatological therapeutics.
As a leading global manufacturer, we prioritize consistency and reliability in every batch. This compound is engineered to meet stringent quality standards required for downstream pharmaceutical applications. The molecular structure features a bromophenoxy group linked to a benzonitrile moiety, providing the necessary reactivity for complex organic synthesis pathways.
Key Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile |
| CAS Number | 906673-45-8 |
| Molecular Formula | C14H10BrNO2 |
| Molecular Weight | 304.14 g/mol |
| Appearance | Off-white to white powder |
| Purity | ≥98.0% |
| Packaging | 25 kg/drum or customized |
Industrial Applications
The primary application of this chemical lies in the manufacturing of Crisaborole, a phosphodiesterase 4 (PDE4) inhibitor. It acts as a pivotal intermediate in the multi-step synthesis route, ensuring the final active pharmaceutical ingredient (API) meets efficacy and safety profiles. Beyond this specific use, the compound serves as a versatile precursor in organic chemistry laboratories exploring novel aromatic substitutions and nitrile functionalizations.
Our supply chain supports large-scale production needs, offering scalable quantities without compromising on quality. Whether for pilot plant studies or commercial manufacturing, this intermediate provides a reliable foundation for process chemistry.
Quality Assurance and Handling
- Rigorous quality control testing including HPLC and NMR analysis.
- Comprehensive Certificate of Analysis (COA) provided with every shipment.
- Packaged in moisture-resistant drums to maintain stability during transit.
- Stored in cool, ventilated facilities to prevent degradation.
- Compliance with international safety and handling regulations.
We understand the importance of supply chain continuity in the pharmaceutical sector. Our facility is equipped to handle bulk orders with flexible packaging options tailored to customer requirements. Technical support is available to assist with synthesis route optimization and integration into your manufacturing process.
