Intermediates

4,5-Difluoro-1H-indole

  • CAS No.247564-63-2
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4,5-Difluoro-1H-indole (CAS 247564-63-2) designed for pharmaceutical R&D and organic synthesis. Reliable supply with comprehensive COA.

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Product Technical Details

Product Overview

4,5-Difluoro-1H-indole is a specialized fluorinated heterocyclic compound serving as a critical building block in modern medicinal chemistry and advanced organic synthesis. As a key intermediate, this substance features a unique substitution pattern that enhances metabolic stability and bioavailability in downstream pharmaceutical applications. Our manufacturing process ensures consistent quality, making it an ideal choice for research institutions and chemical enterprises focused on drug discovery.

The incorporation of fluorine atoms at the 4 and 5 positions of the indole ring significantly alters the electronic properties of the molecule. This modification is highly valued in the development of kinase inhibitors and other therapeutic agents where precise molecular interaction is required. We adhere to strict quality control protocols to guarantee that every batch meets the rigorous standards demanded by the global pharmaceutical industry.

Technical Specifications

Our production facility utilizes state-of-the-art synthesis and purification technologies to deliver products with exceptional purity. The following table outlines the key physical and chemical properties verified through our quality assurance laboratory.

ParameterValue
CAS Number247564-63-2
Molecular FormulaC8H5F2N
Molecular Weight153.129
AppearanceWhite to light yellow crystalline powder
Assay≥98.0%
Density1.4±0.1 g/cm3
Boiling Point264.5±20.0 °C at 760 mmHg
Flash Point113.8±21.8 °C

Industrial Applications

This fluorinated indole derivative is primarily utilized as a versatile intermediate in the synthesis of complex organic molecules. Its primary applications include:

  • Pharmaceutical Research: Used as a core structure for developing novel therapeutic compounds.
  • Agrochemical Development: Serves as a precursor for advanced crop protection agents.
  • Material Science: Employed in the creation of specialized organic electronic materials.
  • Custom Synthesis: Available for tailored research projects requiring specific substitution patterns.

Quality Assurance and Packaging

We understand that consistency is paramount in chemical manufacturing. Each production lot undergoes comprehensive testing using HPLC and NMR spectroscopy to confirm identity and purity. A Certificate of Analysis (COA) is provided with every shipment to ensure full transparency and compliance with your internal quality standards.

Standard packaging consists of 25 kg drums, securely sealed to prevent moisture absorption and contamination. Custom packaging solutions are available upon request to suit specific logistical requirements. Proper storage in a cool, ventilated area is recommended to maintain product integrity over time. Our logistics team ensures safe and timely global delivery, supporting your supply chain efficiency.