4,5-Difluoro-2-Iodobenzoic Acid

Product Overview

4,5-Difluoro-2-Iodobenzoic Acid represents a highly specialized fluorinated aromatic building block essential for modern medicinal chemistry and advanced organic synthesis. This compound features a benzoic acid core substituted with two fluorine atoms at the fourth and fifth positions and an iodine atom at the second position. The presence of the carbon-iodine bond provides a reactive handle for various palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Heck, and Sonogashira couplings. Meanwhile, the fluorine substituents enhance metabolic stability and lipophilicity, making this intermediate particularly valuable in the development of novel pharmaceutical agents and agrochemical formulations. Our manufacturing process ensures high structural integrity and minimal impurity profiles.

As a leading global manufacturer, we understand the critical role of purity in downstream synthesis. This product is synthesized under strictly controlled conditions to meet international quality standards. It serves as a versatile precursor for constructing complex molecular architectures required in drug discovery pipelines. The combination of halogen functionality allows chemists to perform selective transformations, enabling the efficient synthesis of biaryl structures and heterocyclic compounds. Whether used in academic research or industrial scale production, this material provides consistent performance and reliability.

Technical Specifications

The following table outlines the key physical and chemical properties verified through our quality control laboratory. Each batch is accompanied by a Certificate of Analysis to guarantee compliance with specified parameters.

Industrial Applications

This fluorinated intermediate is predominantly utilized in the pharmaceutical industry for the synthesis of kinase inhibitors and receptor modulators. The iodine moiety facilitates late-stage functionalization, allowing chemists to introduce diverse aryl or alkyl groups efficiently. In agrochemical development, it serves as a key building block for herbicides and fungicides where fluorine content improves environmental persistence and biological activity. Additionally, material science researchers employ this compound in the creation of organic electronic materials and liquid crystals due to its specific electronic properties. The high purity level ensures that side reactions are minimized during scale-up processes.

Our clients leverage this chemical for creating complex libraries in high-throughput screening campaigns. The stability of the carboxylic acid group allows for further derivatization into esters, amides, or acid chlorides, expanding the synthetic utility significantly. We support various scales from gram-level research quantities to multi-kilogram production runs, ensuring supply chain continuity for critical projects.

Quality Assurance and Handling

• Strict quality control protocols are implemented at every stage of production.
• Each drum is sealed to prevent moisture absorption and contamination.
• Storage in a cool, ventilated place away from incompatible substances is recommended.
• Packaging options include 25 kg drums or custom solutions based on client requirements.
• Comprehensive documentation including COA, MSDS, and method validation is provided.

We are committed to delivering excellence in every shipment. Our logistics team ensures safe and timely delivery globally. For specific technical inquiries or custom synthesis requests, our expert support team is available to assist with formulation guidance and process optimization. Trust our experienced facility for your critical chemical sourcing needs.