4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine
- CAS No.145783-14-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
Premium grade 4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine designed for efficient Ticagrelor synthesis. Available in bulk with verified COA and strict quality control.
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Product Overview
4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine represents a critical advanced organic synthesis intermediate within the pharmaceutical industry. Specifically engineered for high-efficiency coupling reactions, this pyrimidine derivative serves as a foundational building block in the manufacturing of novel cardiovascular therapeutics. Our production facilities adhere to rigorous international standards, ensuring that every batch delivers consistent molecular integrity and exceptional purity profiles required for complex drug synthesis pathways.
As a specialized chemical entity, this compound facilitates key structural modifications during the multi-step synthesis of antiplatelet agents. The presence of chloro, nitro, and propylthio functional groups provides versatile reactivity, allowing medicinal chemists to execute precise nucleophilic substitutions. We understand that the quality of intermediates directly impacts the yield and safety of the final active pharmaceutical ingredient, which is why our quality assurance protocols are uncompromising.
Technical Specifications
Our manufacturing process utilizes state-of-the-art purification technologies to minimize impurities and by-products. The physical and chemical properties are strictly monitored to ensure compatibility with downstream processing conditions. Below are the verified specifications for our commercial grade supply:
| Parameter | Specification |
|---|---|
| CAS Number | 145783-14-8 |
| Molecular Formula | C7H7Cl2N3O2S |
| Molecular Weight | 268.120 g/mol |
| Appearance | Yellow to brown liquid |
| Assay (HPLC) | ≥95.0% |
| Moisture Content | ≤1.0% |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 377.8±37.0 °C at 760 mmHg |
| Flash Point | 182.3±26.5 °C |
Industrial Applications and Advantages
This intermediate is primarily utilized in the synthesis route of Ticagrelor, a potent P2Y12 inhibitor used in the management of acute coronary syndromes. The high purity level of our 4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine ensures minimal formation of difficult-to-remove impurities during subsequent reaction steps. This efficiency translates to reduced production costs and shorter cycle times for pharmaceutical manufacturers.
- High reactivity for nucleophilic substitution reactions.
- Optimized stability for long-term storage and transport.
- Consistent batch-to-batch reproducibility for scale-up production.
- Compatible with various solvent systems used in industrial processing.
- Supports custom synthesis requirements for specific project needs.
Storage and Handling Safety
Proper handling of this chemical intermediate is essential to maintain its quality and ensure workplace safety. The product should be stored in a cool, ventilated place away from direct sunlight and sources of ignition. Containers must be kept tightly closed when not in use to prevent moisture absorption, which could degrade the assay quality over time. Personnel handling this material should wear appropriate personal protective equipment, including chemical-resistant gloves and safety goggles, to prevent skin contact or eye irritation. In case of spills, standard chemical containment procedures should be followed immediately to prevent environmental contamination.
We offer flexible packaging options, including standard 25 kg drums, to accommodate various production scales. Our global logistics network ensures timely delivery while maintaining the integrity of the product throughout the supply chain. For detailed safety data sheets and certificates of analysis, please contact our technical support team.
