Intermediates

4,6-Difluoro-1H-indole-2-carboxylic acid

  • CAS No.247564-66-5
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4,6-Difluoro-1H-indole-2-carboxylic acid (CAS 247564-66-5) designed for advanced organic synthesis. Reliable supply with ≥97.0% assay for pharmaceutical intermediates.

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Product Technical Details

Product Overview

Welcome to our detailed specification page for 4,6-Difluoro-1H-indole-2-carboxylic acid. This specialized chemical intermediate represents a critical component in modern organic synthesis and medicinal chemistry research. As a fluorinated indole derivative, this compound offers unique structural properties that are highly valued in the development of complex pharmaceutical agents and advanced materials. Our facility is dedicated to providing consistent quality and reliable supply chains for global research institutions and industrial partners.

The molecular architecture of this compound features a robust indole scaffold substituted with fluorine atoms at the 4 and 6 positions. This specific substitution pattern enhances metabolic stability and lipophilicity, making it an excellent building block for drug discovery programs. We understand the stringent requirements of modern chemical synthesis, which is why our production processes are optimized to deliver high purity levels suitable for sensitive downstream applications.

Key Specifications

Quality control is the cornerstone of our manufacturing philosophy. Each batch of 4,6-Difluoro-1H-indole-2-carboxylic acid undergoes rigorous analytical testing to ensure compliance with international standards. The physical and chemical properties are carefully monitored to guarantee performance consistency in your synthesis workflows. Below are the typical specifications for our commercial grade material.

ParameterSpecification
CAS Number247564-66-5
Molecular FormulaC9H5F2NO2
Molecular Weight197.138
AppearanceOff-white powder
Assay (Purity)≥97.0%
Density1.6±0.1 g/cm3
Boiling Point414.7±40.0 °C at 760 mmHg
Flash Point204.6±27.3 °C

Industrial Applications

This fluorinated indole derivative serves as a versatile intermediate in the synthesis of various bioactive molecules. Its primary application lies in the pharmaceutical sector, where it acts as a precursor for kinase inhibitors and other therapeutic agents targeting neurological or oncological pathways. The presence of fluorine atoms often improves the binding affinity and pharmacokinetic profiles of the final drug candidates.

  • Pharmaceutical intermediate for novel drug discovery
  • Building block for heterocyclic compound synthesis
  • Research reagent for organic chemistry laboratories
  • Component in advanced material science applications

Beyond pharmaceuticals, this compound is utilized in the development of specialized agrochemicals and functional materials. The stability of the carboxylic acid group allows for diverse chemical transformations, including amidation and esterification, providing chemists with flexibility in designing synthetic routes. Our technical team can support custom synthesis requests to meet specific project requirements.

Storage and Handling

Proper storage is essential to maintain the integrity of 4,6-Difluoro-1H-indole-2-carboxylic acid. We recommend storing the material in a cool, ventilated place away from direct sunlight and moisture. The packaging is designed to protect the product during transit, typically supplied in 25 kg drums unless custom packaging is requested. Safety data sheets and certificates of analysis are provided with every shipment to ensure compliance with local regulations.

Our commitment to excellence extends beyond the product itself. We offer comprehensive logistical support, ensuring timely delivery to destinations worldwide. Whether you require bulk quantities for large-scale production or smaller amounts for research purposes, our team is equipped to handle your orders with professionalism and efficiency. Contact us today to discuss your specific needs and request a competitive quote for this high-value chemical intermediate.